Maurizio Isola

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Tramadol is a synthetic opioid agonist used extensively in human and, to a lesser extent, veterinary medicine throughout the world. The clinical efficacy and pharmacokinetic profile of intravenous (i.v.) and extradural (e.d.) tramadol (2 mg/kg) and its o-desmethyl metabolite were studied in dogs undergoing tibial plateau levelling osteotomy (TPLO).(More)
The nature of chemical defenses in poison frogs has been explored in a variety of species, and most studies focus on the types of chemical defenses and their sources. The defensive compounds of frogs are stored in dermal granular glands that have been described for several species that are chemically protected from predators and/or microorganisms. Gland(More)
We have identified the presence of type I collagen (COLL1alpha) mRNA in Paracentrotus lividus unfertilized egg, indicating a maternal origin of this mRNA. By in situ whole mount hybridization the spatial distribution of COLL1alpha mRNA in egg and embryo at different developmental stages was established. Moreover, the presence of COLL1alpha gene in(More)
This study investigated the effect of extremely low-frequency pulsed electromagnetic fields (PEMFs) on skin wound healing in an in vitro dermal-like tissue. In this study, fibroblast and endothelial cells were utilized for the in vitro reconstruction of dermal-like tissues treated for various times up to 21 days with PEMFs. The effects of PEMFs on cell(More)
Although sheep are widely used as an experimental model for various surgical procedures there is a paucity of data on the pharmacokinetics and efficacy of analgesic drugs in this species. The aims of this study were to investigate the pharmacokinetics of intravenously (IV) administered tramadol and its active metabolite O-desmethyltramadol (M1) and to(More)
OBJECTIVE To define and validate a method for the measurement of 3-dimensional (3D) morphometric parameters in polygonal mesh models of canine femora. STUDY DESIGN Ex vivo/computerized model. SAMPLE POPULATION Sixteen femora from 8 medium to large-breed canine cadavers (mean body weight 28.3 kg, mean age 5.3 years). METHODS Femora were measured with a(More)
Pharmacogenomics, the science of how genetic makeup influences an individual's reaction to drugs, is an innovative tool for providing critical insights into how a patient will respond to a particular treatment. In the present work, we constructed cancer-like tissues to be used as tools for determining the most effective drug for an individual patient. Using(More)
Letizia Ferroni1, Chiara Gardin1, Eriberto Bressan2, José L. Calvo-Guirado3, Maurizio Isola4, Adriano Piattelli5, and Barbara Zavan1 ∗ 1Department of Biomedical Sciences, University of Padova, Viale Giuseppe Colombo, 3, 35131 Padova, Italy 2Department of Neurosciences, University of Padova, Via Giustiniani, 2, 35131 Padova, Italy 3Department of General(More)
M.C. Veronesi1*, M. Battocchio1, F. Cairoli1, A. Comin2 and M. Isola3 1Istituto di Clinica Ostetrica e Ginecologica Veterinaria, Facoltà di Medicina Veterinaria, Università di Milano, Milano; 2Dipartimento di Scienze Alimentari, Facoltà di Medicina Veterinaria, Università di Udine, Udine; 3Cattedra di Biometria e Statistica Medica, Facoltà di Medicina,(More)