BACKGROUND Little evidence-based information is available to guide the treatment of oligoarticular juvenile idiopathic arthritis. We aimed to investigate whether oral methotrexate increases the efficacy of intra-articular corticosteroid therapy. METHODS We did this prospective, open-label, randomised trial at ten hospitals in Italy. Using a concealed… (More)
A controlled trial of intra-articular corticosteroids with or without methotrexate in oligoarticular juvenile idiopathic arthritis
To evaluate disease course in juvenile idiopathic arthritis (JIA) by applying newly developed preliminary definitions of remission, to assess probability of relapse of disease. Charts of patients with JIA followed since 1970 were reviewed. First episode of remission off medication status, as defined by Wallace et al., has been focused. The cohort included… (More)
The aim of our study was to prospectively evaluate bone density in adolescents females with JIA, and to correlate the results with puberty. Lumbar spine (L2–L4) areal bone mineral density (aBMD) (assessed by Dual X-ray Absorb-iometry, DXA) was monitored every 6–12 months in a group of 38 girls with JIA. The evaluated bone density accrual during the… (More)
CRMO is an autoinflammatory disease of children and young adults, characterized by the insidious onset of local pain and swelling in affected bone and fever. The bone lesions are radiologically characterized as multiple luciens surrounded by defined zones of patchy but dense sclerosis , cortical tickening from periosteal new bone formation , and increased… (More)
Objectives To determine the efficacy of a second treatment with a different TNF blocker in JIA when the first one failed. Methods All JIA patients prospectively followed at our Centre, who failed a first TNF blocker and switched to a second one were enrolled. For each patient the DAS, ACR Ped30, ACR20, ACR50 and ACR70 responses were evaluated at baseline… (More)
Objective To evaluate efficacy and safety of Anakinra in SoJIA non responsive to antiTNF.