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BACKGROUND Brain natriuretic peptide (BNP) and norepinephrine (NE) are strongly related to severity of and are independent predictors of outcome in heart failure. The long-term effects of angiotensin receptor blockers on BNP and NE in heart failure patients are not known. METHODS AND RESULTS Both BNP and NE were measured in 4284 patients randomized to(More)
This paper presents a 'Lexicographic' Goal Programming (LGP) approach to define the best strategies for the maintenance of critical centrifugal pumps in an oil refinery. For each pump failure mode, the model allows to take into account the maintenance policy burden in terms of inspection or repair and in terms of the manpower involved, linking them to(More)
The calcium-sensing receptor (CaSR) has been detected in human antral gastrin-secreting cells, where, upon calcium and/or amino acid allosteric activation, it stimulates gastrin secretion. Patients with absorptive hypercalciuria (AH) display an enhanced gastric acid output; therefore, we evaluated the secretion of gastrin in subjects with AH (30 subjects(More)
BACKGROUND It is known that bone mineral density (BMD) predicts the fracture's risk only partially and the severity and number of vertebral fractures are predictive of subsequent osteoporotic fractures (OF). Spinal deformity index (SDI) integrates the severity and number of morphometric vertebral fractures. Nowadays, there is interest in developing(More)