Mauricio García-Alonso

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BACKGROUND Transforming growth factor beta (TGF-β1) is a pleiotropic cytokine, which is deregulated in atherosclerosis; however the role of age in this process is unknown. We aimed to assess whether TGF-β1 signaling is affected by age. METHODS Vascular smooth muscle cells (VSMC) were obtained from patients undergoing abdominal surgery. Levels of TGF-β1(More)
Phenylephrine (PE)-induced oscillatory fluctuations in intracellular Ca(2+) concentration ([Ca(2+)]i) of vascular smooth muscle have been observed in many blood vessels isolated from a wide variety of mammals. Paradoxically, until recently similar observations in humans have proven elusive. In this study, we report for the first time observations of(More)
In 2008 he was diagnosed with a rectal adenocarcinoma (pT3N0M0) and villous adenoma at 11 and 4 cm from the anal margin, respectively. Short-course radiotherapy (25 Gy in 5 Gy daily fractions) was administered and the patient underwent anterior rectal resection plus perianal adenoma resection. During follow-up a positron emission tomograph was performed(More)
Summary Background. Anisakis simplex hypersensitive subjects may be sensitized without clinical allergy, or experience acute symptoms or chronic urticaria induced by raw fish. We studied whether the 3 subgroups differ in IgE, IgG1 or IgG4 reactivity to specific Anisakis simplex allergens. Methods. 28 Anisakis simplex-hypersensitive adults, 11 with acute(More)
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