Maurice O. Iwunze

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Spectroscopic (fluorescence and absorptiometric) techniques were used to study the interaction between peroxynitrite, a known biological stressor, and curcumin, a potent biological antioxidant. In both techniques, the observed signals increased asymptotically until the concentration of peroxynitrite equals that of the curcumin, which was held constant at 1(More)
Peroxynitrite, a potent albeit deleterious biological oxidant, was electrooxidized at a bare platinum electrode in a medium of simulated body fluid (SBF) to nitrite anion and molecular oxygen. The SBF, prepared in accordance with literature procedure, has a pH of 7.4 and an ionic strength of 0.16. In this medium, peroxynitrite was observed to undergo a(More)
Soybean oil (SBO) is used as a medium to solubilize zinc phthalocyanine (ZnPc), a known photosensitizer, which has been found to be of potential use in photodynamic therapy. It absorbs red light in this medium at 670 nm with good molar absorptivity comparable to its value in most organic solvents (2.45 x 10(5) M(-1) cm(-1)). The wavelength of the(More)
Steady-state fluorescence spectro-photometric technique is used in this work to determine the chemical parameters of the complex formed between curcumin and ascorbic acid in bicontinuous microemuslion (Bμen). The Bμen liquid used is made up of a four-components system (water–oil-surfactant and co-surfactant (1-pentanol)) in the ratio of(More)
Steady state fluorescence spectroscopy is used to study the binding characteristics of zinc phthalocyanine (ZnPc) to MCF-7 human breast cancer cells solubilized in a liposomal vesicle prepared with L-alpha-phosphatidic acid, dipalmitoyl. The observed apparent binding constant, K', of 1.14 x 10(7) together with the free energy of binding, deltaG, of -40.38(More)
Curcumin, a known phytochemical antioxidant was found to be useful as a potential sensor for some small biologically important molecules. Hydrogen peroxide, the sodium salt of nitrite (NO2-), hydroxide (OH-), bromide (Br-) and iodide (I-) were observed to quench the fluorescence of sol-gel encapsulated curcumin, which emits radiation at 530 nm when excited(More)
Biocontinuous microemulsions of didodecyldimethylammonium bromide (DDAB)/dodecane/water were explored as media for voltammetric reductions and oxidations of ruthenium(III) hexaammine, ferrocyanide, ferrocene, cob(II)alamin, and several polycyclic aromatic hydrocarbons (PAHs). These clear microemulsions are conductive and are believed to contain a dynamic(More)
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