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Previously we have employed antibodies to the tight junction (TJ)-associated proteins ZO-1 and occludin to describe endothelial tight junction abnormalities, in lesional and normal appearing white matter, in primary and secondary progressive multiple sclerosis (MS). This work is extended here by use of antibodies to the independent TJ-specific proteins and(More)
OBJECTIVE To evaluate the change in hemoglobin A1C (A1C) in patients with type 2 diabetes switched from coadministration of a sulfonylurea (SU), glyburide or glipizide, and metformin (SU+Met) to a single glyburide-metformin tablet. METHODS A retrospective cohort study design of patients with type 2 diabetes treated at 3 Veterans Affairs Medical Centers(More)
The patient-centered medical home (PCMH) is a primary care model that aims to provide quality care that is coordinated, comprehensive, and cost-effective. PCMH is hinged upon building a strong patient-provider relationship and using a team-based approach to care to increase continuity and access. It is anticipated that PCMH can curb the growth of health(More)
  • M Padden
  • 1998
In October 1997, a New York court rejected an attempt by the U.S. Department of Justice (DOJ) to block the merger of two New York teaching hospitals. The DOJ's case was based, in part, on the premise that the consumers in the hospitals' market were managed care organizations, which needed prestigious teaching hospitals to "anchor" their healthcare delivery(More)
This case study describes the Military Health System's (MHS) patient-centered medical home (PCMH) initiative and how it is being delivered across the MHS by the Army, Navy, and Air Force. The MHS, an integrated delivery model that includes both military treatment facilities and civilian providers and health care institutions, is transforming its primary(More)
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