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Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
It is shown that the C/C genotype strongly enhances resolution of HCV infection among individuals of both European and African ancestry, the strongest and most significant genetic effect associated with natural clearance ofHCV.
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
The strongest synergistic effect of these loci was on progression to depletion of CD4+ T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection.
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
It is reported that interleukin-1 gene cluster polymorphisms suspected of enhancing production of interleucine-1-beta are associated with an increased risk of both hypochlorhydria induced by H. pylori and gastric cancer.
HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
The various epistatic effects observed here for common, distinct KIR3DL1 and HLA-B Bw4 combinations are unprecedented with regard to any pair of genetic loci in human disease, and indicate that NK cells may have a critical role in the natural history of HIV infection.
A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection
It is proposed that L-SIGN may play an important role in the interaction between liver sinusoidal endothelium and trafficking lymphocytes, as well as function in the pathogenesis of HIV-1.
Timing of the Last Glacial Maximum from observed sea-level minima
The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense.
- A. Bashirova, Maureen P. Martin, D. McVicar, M. Carrington
- BiologyAnnual review of genomics and human genetics
- 1 September 2006
The polymorphism of the KIR locus parallels that of the MHC, facilitating the adaptation of the immune system to a dynamic, challenging environment.
Differential natural killer cell–mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes
- G. Alter, Maureen P. Martin, M. Altfeld
- Biology, MedicineThe Journal of experimental medicine
- 26 November 2007
The functional ability of NK cells to differentially control HIV-1 replication in vitro based on their KIR and HLA types is examined, providing the first functional evidence that variation at the KIR locus influences the effectiveness of NK cell activity in the containment of viral replication.
Global diversity and evidence for coevolution of KIR and HLA
Activating receptor-ligand pairs in this study show the strongest signature of coevolution of these two complex genetic systems as compared with inhibitory receptor- ligand pairs.