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In 2006, C. F. Bond Jr. and B. M. DePaulo provided a meta-analysis of means and concluded that average lie detection accuracy was significantly greater than chance for most people. Now, they have presented an analysis of standard deviations (C. F. Bond Jr. & B. M. DePaulo, 2008), claiming that there are no reliable individual differences in lie detection(More)
Human chromosome 14q32.2 harbors the germline-derived primary DLK1-MEG3 intergenic differentially methylated region (IG-DMR) and the postfertilization-derived secondary MEG3-DMR, together with multiple imprinted genes. Although previous studies in cases with microdeletions and epimutations affecting both DMRs and paternal/maternal uniparental disomy 14-like(More)
Bond and Uysal (this issue) complain that expert lie detectors identified by O'Sullivan and Ekman (2004) are statistical flukes. They ignore one class of experts we have identified and misrepresent the procedures we use to identify the others. They also question the psychometric validity of the measures and protocol used. Many of their points are addressed(More)
BACKGROUND Neuroblastoma is a paediatric cancer of the sympathetic nervous system. The single most important genetic indicator of poor clinical outcome is amplification of the MYCN transcription factor. One of many down-stream MYCN targets is miR-184, which is either directly or indirectly repressed by this transcription factor, possibly due to its(More)
MiRNAs regulate gene expression at a post-transcriptional level and their dysregulation can play major roles in the pathogenesis of many different forms of cancer, including neuroblastoma, an often fatal paediatric cancer originating from precursor cells of the sympathetic nervous system. We have analyzed a set of neuroblastoma (n = 145) that is broadly(More)
Malingering occupies a range on a continuum from biased self-perception to conscious, deliberate, serious lies. One aspect of this continuum is the element of self-conscious or deliberate control. Suggestions from Darwin's writings concerning the role of voluntary and involuntary activation of the facial muscles are examined and illustrated with data from a(More)
Most people are unable to detect accurately when others are lying. Many explanations for this inability have been suggested but the cognitive heuristics involved in lie detection have received little attention. The present study offers evidence from two experiments, based on two different groups of observers, judging two different kinds of lies, presented(More)
We have created a high quality phage display library containing over 1010 human antibodies and describe its use in the generation of antibodies on an unprecedented scale. We have selected, screened and sequenced over 38,000 recombinant antibodies to 292 antigens, yielding over 7,200 unique clones. 4,400 antibodies were characterized by specificity testing(More)
A case of traumatic extracranial vertebral arterial dissection leading to vertebrobasilar thrombosis and respiratory compromise requiring mechanical ventilation was managed with intraarterial thrombolysis and stenting of the vertebral intimal dissection. In contrast to similar, previously reported cases, this critically ill patient made a full recovery,(More)