Maureen L. Condic

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The primary mediators of cell migration during development, wound healing and metastasis, are receptors of the integrin family. In the developing and regenerating nervous system, chondroitin sulfate proteoglycans (CSPGs) inhibit the integrin-dependent migration of neuronal growth cones. Here we report that embryonic sensory neurons cultured on the(More)
Imaginal discs of Drosophila are simple epithelial tissues that undergo dramatic changes in shape during metamorphosis, including elongation to form adult appendages such as legs and wings. We have examined the cellular basis of leg disc morphogenesis by staining filamentous actin to outline cell boundaries in discs and observing cell shapes with scanning(More)
The differentiation and morphogenesis of neural tissues involves a diversity of interactions between neural cells and their environment. Many potentially important interactions occur with the extracellular matrix (ECM), a complex association of extracellular glycoproteins organized into aggregates and polymers. In this article, we discuss recent findings on(More)
Transition from symmetry to asymmetry is a central theme in cell and developmental biology. In Xenopus embryos, dorsal-ventral asymmetry is initiated by a microtubule-dependent cytoplasmic rotation during the first cell cycle after fertilization. Here we show that the cytoplasmic rotation initiates differential cytoplasmic polyadenylation of maternal(More)
The Ti1 afferent neurons are the first cells to undergo axonogenesis in embryonic grasshopper limbs. The Ti1 growth cones migrate between the limb epithelium and its basal lamina. We have investigated the nature of growth conebasal lamina interactions in vivo by removing the basal lamina with mild enzymatic digestion. Treatment with elastase, ficin, or(More)
In a variety of adult CNS injury models, embryonic neurons exhibit superior regenerative performance when compared with adult neurons. It is unknown how young neurons extend axons in the injured adult brain, in which adult neurons fail to regenerate. This study shows that cultured adult neurons do not adapt to conditions that are characteristic of the(More)
The Ti1 pioneer neurons of embryonic grasshopper limbs extend axons between the limb epithelium and its basal lamina. Their growth cones exhibit high affinity for both limb segment boundaries and immature neurons. We have investigated the role of the basal lamina in growth cone adhesion to neurons and segment boundaries by removing the basal lamina with(More)
The contribution of the basal lamina to Ti1 pioneer axon guidance in grasshopper limb buds was investigated by allowing growth cones to migrate in 30%-31% stage limbs from which the basal lamina had been removed by enzymatic treatment. When the Ti1 axons extended from their normal location, the pathways established in the absence of basal lamina were(More)
The molecular mechanisms that control the axon pathfinding of different subtypes of dorsal root ganglia (DRG) neurons are poorly understood. To address whether Netrin-1-Neogenin/UNC-5 signaling contributes to sensory axon pathfinding, we cloned chick UNC5 homolog 3 (cUNC-5H3) and characterized the spatial, cellular and temporal expression patterns of(More)
Receptors of the integrin family are expressed by every cell type and are the primary means by which cells interact with the extracellular matrix. The control of integrin expression affects a wide range of developmental and cellular processes, including the regulation of gene expression, cell adhesion, cell morphogenesis and cell migration. Here we show(More)