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We investigated whether preventing hyperglycemia in septic patients affected the plasma concentration of asymmetric-dimethylarginine and if this was associated with clinical benefit. A prospective, multicenter, randomized, controlled, clinical study. Intensive care units (ICU) in three university hospitals. A total of 72 patients admitted for severe sepsis(More)
OBJECTIVE To investigate whether the vasopressin analog terlipressin might induce hepatosplanchnic ischemia during long-term, hyperdynamic, volume-resuscitated porcine endotoxemia. DESIGN Prospective, randomized, controlled experimental study with repeated measures. SETTING Investigational animal laboratory. SUBJECTS Eighteen pigs were divided into(More)
Inhibition of poly (ADP-ribose) polymerase 1 (PARP-1) improved hemodynamics and organ function in various shock models induced by sepsis or ischemia/reperfusion. PARP-1, however, is also referred to play a pivotal role for the maintenance of genomic integrity. Therefore, we investigated the effect of the PARP-1 blocker INO-1001 on hemodynamics, kidney(More)
We previously reported in healthy volunteers that a cantaloupe melon extract chemically combined with wheat gliadin (melon extract/gliadin) and containing SOD, catalase and residual glutathione peroxidase (GPx), protected against DNA strand-break damage induced by hyperbaric oxygen (HBO), a well-established model of DNA damage resulting from oxidative(More)
To investigate the hemodynamic and metabolic effects of the peroxisome proliferator-activated receptor (PPAR)-γ ligand and nuclear-factor (NF)-κ B inhibitor 15-deoxy-Δ12,14-prostaglandin-J2 (15d-PGJ2) during long-term, hyperdynamic porcine endotoxemia. Prospective, randomized, controlled experimental study with repeated measures. Investigational animal(More)
BACKGROUND & AIMS Within a prospective study on costs in 45 Italian intensive units we reviewed nutrition support practice given during critical illness. METHODS From June to October 1999, patients with an ICU stay longer than 47 h were studied. Nutrition (i.e. fasting, parenteral, enteral and mixed) and calorie supply by the enteral route were monitored(More)
AIM The aim of this study was to update the current practice of pharmacological sedation and analgesia in Italian intensive care units. METHODS DESIGN observational, prospective, cohort study involving consecutive patients admitted during 5 months in 1999. PATIENTS were evaluated for the first 7 days of high-level-of care. SETTING 45 adult general(More)
AIM Asymmetric and symmetric dimethylarginines (ADMA and SDMA, respectively) are protein breakdown markers; both compete with arginine for cellular transport and both are excreted in urine. Moreover, ADMA is a non-selective inhibitor of nitric oxide (NO) synthase that is metabolized by a specific hydrolase in which the activity during stress remains(More)
BACKGROUND To establish the effectiveness of ICU treatment and the efficiency in the use of resources in patients stratified according to 10 diagnosis and two levels-of-care. To propose strategies aimed at reducing costs and improving efficiency in each patient group. METHODS Multicentre prospective observational study. ICUs enrolled two cohorts of up to(More)
OBJECTIVE To investigate the systemic, pulmonary, and hepatosplanchnic hemodynamic and metabolic effects of delayed treatment with ethyl pyruvate in a long-term porcine model of hyperdynamic endotoxemia. DESIGN Prospective, randomized, controlled experimental study with repeated measures. SETTING Investigational animal laboratory. SUBJECTS(More)