Maurício C Rocha–Junior

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Background Polymorphisms in promoter region of IL-18 genes have been studied in many chronic inflammatory and infectious disorders. For instance, the IL-18 -137 GG and -607CC polymorphisms have been associated with elevated expression of IL-18, which could contribute for the inflammatory process and favor the antiviral effects of this cytokine. In this(More)
Background Interferon-gamma (INF-g) is a key cytokine involved in the defense against intracellular pathogens, such as HTLV-1, by coordinating the expression of immunologically relevant genes. Previous studies showed the importance of this cytokine on HTLV-1-related pathogenesis. Thus, we have investigated the possible association between IFN-g gene(More)
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