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- Pascal MASSART, Marc Lavielle, +8 authors OMTE MLX
- 2009

- Céline Lévy-Leduc, Maud Delattre, Tristan Mary-Huard, Stéphane Robin
- Bioinformatics
- 2014

MOTIVATION
The spatial conformation of the chromosome has a deep influence on gene regulation and expression. Hi-C technology allows the evaluation of the spatial proximity between any pair of loci along the genome. It results in a data matrix where blocks corresponding to (self-)interacting regions appear. The delimitation of such blocks is critical to… (More)

We consider N independent stochastic processes (Xi(t), t ∈ [0, Ti]), i = 1, . . . , N , defined by a stochastic differential equation with drift term depending on a random variable φi. The distribution of the random effect φi depends on unknown parameters which are to be estimated from the continuous observation of the processes Xi. We give the expression… (More)

Abstract We consider N independent stochastic processes (Xi(t), t ∈ [0, Ti]), i = 1, . . . , N , defined by a stochastic differential equation with drift term depending on a random variable φi. The distribution of the random effect φi is a Gaussian mixture distribution, depending on unknown parameters which are to be estimated from the continuous… (More)

We consider N independent stochastic processes (Xi(t), t ∈ [0, Ti]), i = 1, . . . , N , defined by a stochastic differential equation with diffusion coefficients depending on a random variable φi. The distribution of the random effect φi depends on unknown population parameters which are to be estimated from a discrete observation of the processes (Xi). The… (More)

- Maud Delattre, Radojka M. Savic, Raymond Miller, Mats O. Karlsson, Marc Lavielle
- Journal of Pharmacokinetics and Pharmacodynamics
- 2012

We propose to describe exposure–response relationship of an antiepileptic agent, using mixed hidden Markov modeling methodology, to reveal additional insights in the mode of the drug action which the novel approach offers. Daily seizure frequency data from six clinical studies including patients who received gabapentin were available for the analysis. In… (More)

- Pierre Colin, Sandrine Micallef, Maud Delattre, Pierre Mancini, Eric Parent
- Statistics in medicine
- 2015

Following the pattern of phase I clinical trials for cytotoxic drugs, dose-finding clinical trials in oncology of molecularly targeted agents (MTA) aim at determining the maximum tolerated dose (MTD). In classical phase I clinical trials, MTD is generally defined by the number of patients with short-term major treatment toxicities (usually called… (More)

— The aim of the present paper is to document the need for adapting the definition of hidden Markov models (HMM) to population studies, which rigorous interpretation typically requires the use of mixed-effects models, as well as for corresponding learning methodologies. In this article, mixed hidden Markov models (MHMM) are introduced through a brief state… (More)

We consider the problem of variable selection in general nonlinear mixed-eets models, including mixed-eects hidden Markov models. These models are used extensively in the study of repeated measurements and longitudinal analysis. We propose a Bayesian Information Criterion (BIC) that is appropriate for nonstandard situations where both the number of subjects… (More)

- Maud Delattre, Marc Lavielle
- Computational Statistics & Data Analysis
- 2012