Maud Delattre

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937 Analyse de séries pluviométriques de longue durée en Afrique de l'Ouest et Centrale non sahélienne dans un contexte de variabilité climatique Résumé Dans les zones arides et semi-arides d'Afrique de l'Ouest et Centrale, la notion de précarité de la ressource en eau n'est pas récente. Cependant, la sécheresse qui affecte les régions tropicales africaines(More)
MOTIVATION The spatial conformation of the chromosome has a deep influence on gene regulation and expression. Hi-C technology allows the evaluation of the spatial proximity between any pair of loci along the genome. It results in a data matrix where blocks corresponding to (self-)interacting regions appear. The delimitation of such blocks is critical to(More)
We propose to describe exposure–response relationship of an antiepileptic agent, using mixed hidden Markov modeling methodology, to reveal additional insights in the mode of the drug action which the novel approach offers. Daily seizure frequency data from six clinical studies including patients who received gabapentin were available for the analysis. In(More)
We consider the problem of variable selection in general nonlinear mixed-eets models, including mixed-eects hidden Markov models. These models are used extensively in the study of repeated measurements and longitudinal analysis. We propose a Bayesian Information Criterion (BIC) that is appropriate for nonstandard situations where both the number of subjects(More)
— The aim of the present paper is to document the need for adapting the definition of hidden Markov models (HMM) to population studies, which rigorous interpretation typically requires the use of mixed-effects models, as well as for corresponding learning methodologies. In this article, mixed hidden Markov models (MHMM) are introduced through a brief state(More)
From the complexity of drug absorption analysis to the minimal modeling for biopharmaceutical classification purposes: A re-appraisal Semi-mechanistic modeling of absorption from extended release formulations-linking in-vitro to in-vivo Predicting product drug absorption performance: BCS and quality by design; kinetic considerations and regulatory(More)
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