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- Publications
- Influence
Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence
- O. Zhang, F. Hsu, W. Xu, Mattie C. Pawlowic, Kai Zhang
- Biology, Medicine
- Molecular microbiology
- 1 November 2013
Sphingosine kinase is a key enzyme in sphingolipid metabolism, catalysing the conversion of sphingosine or dihydrosphingosine into sphingosine‐1‐phosphate or dihydrosphingosine‐1‐phosphate… Expand
Leishmania parasites possess a platelet-activating factor acetylhydrolase important for virulence.
- Mattie C. Pawlowic, Kai Zhang
- Biology, Medicine
- Molecular and biochemical parasitology
- 1 November 2012
Leishmania parasites are intracellular protozoans capable of salvaging and remodeling lipids from the host. To understand the role of lipid metabolism in Leishmania virulence, it is necessary to… Expand
Plasmenylethanolamine synthesis in Leishmania major
- Mattie C. Pawlowic, F. Hsu, Samrat Moitra, Neha Biyani, Kai Zhang
- Biology, Medicine
- Molecular microbiology
- 1 July 2016
Ethanolamine glycerophospholipids are ubiquitous cell membrane components. Trypanosomatid parasites of the genus Leishmania synthesize the majority of their ethanolamine glycerophospholipids as… Expand
Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major
- Samrat Moitra, Mattie C. Pawlowic, F. Hsu, K. Zhang
- Chemistry, Medicine
- Scientific Reports
- 20 May 2019
Phosphatidylcholine (PC) is a major cell membrane constituent and precursor of important second messengers. In Leishmania parasites, PC synthesis can occur via the choline branch of the Kennedy… Expand
De novo synthesis of phosphatidylcholine is essential for the promastigote but not amastigote stage in Leishmania major
- Samrat Moitra, Somrita Basu, Mattie C. Pawlowic, F. Hsu, K. Zhang
- Biology
- 30 December 2020
Phosphatidylcholine (PC) is the most abundant type of phospholipids in eukaryotes constituting ~30% of total lipids in Leishmania. PC synthesis mainly occurs via the choline branch of the Kennedy… Expand