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Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence
Sphingosine kinase is a key enzyme in sphingolipid metabolism, catalysing the conversion of sphingosine or dihydrosphingosine into sphingosine‐1‐phosphate or dihydrosphingosine‐1‐phosphateExpand
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Phospholipid metabolism of Leishmania parasites
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Leishmania parasites possess a platelet-activating factor acetylhydrolase important for virulence.
Leishmania parasites are intracellular protozoans capable of salvaging and remodeling lipids from the host. To understand the role of lipid metabolism in Leishmania virulence, it is necessary toExpand
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Plasmenylethanolamine synthesis in Leishmania major
Ethanolamine glycerophospholipids are ubiquitous cell membrane components. Trypanosomatid parasites of the genus Leishmania synthesize the majority of their ethanolamine glycerophospholipids asExpand
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Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major
Phosphatidylcholine (PC) is a major cell membrane constituent and precursor of important second messengers. In Leishmania parasites, PC synthesis can occur via the choline branch of the KennedyExpand
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De novo synthesis of phosphatidylcholine is essential for the promastigote but not amastigote stage in Leishmania major
Phosphatidylcholine (PC) is the most abundant type of phospholipids in eukaryotes constituting ~30% of total lipids in Leishmania. PC synthesis mainly occurs via the choline branch of the KennedyExpand