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Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique to modulate cortical excitability. Although increased/decreased excitability under the anode/cathode electrode is nominally associated with membrane depolarization/hyperpolarization, which cellular compartments (somas, dendrites, axons and their terminals) mediate(More)
Uniform steady state (DC) electric fields, like those generated during transcranial direct current stimulation (tDCS), can affect neuronal excitability depending on field direction and neuronal morphology. In addition to somatic polarization, subthreshold membrane polarization of axon compartments can play a significant role in modulating synaptic efficacy.(More)
of early nonmotor features and risk factors for Parkinson disease. mutations influence the natural history of Parkinson's disease in a community-based incident cohort. and worldwide genetic penetrance of LRRK2-associated Parkin-son's disease: a case-control study. The future of deep brain stimulation (DBS) for Parkinson's disease (PD) lies in new(More)
Quantitative electroencephalography (qEEG) showed that Alzheimer's disease (AD) is characterized by increased theta power, decreased alpha and beta power, and decreased coherence in the alpha and theta band in posterior regions. These abnormalities are thought to be associated with functional disconnections among cortical areas, death of cortical neurons,(More)
Compared to conventional deep brain stimulation (DBS) for patients with Parkinson's Disease (PD), the newer approach of adaptive DBS (aDBS), regulating stimulation on the basis of the patient's clinical state, promises to achieve better clinical outcomes, avoid adverse-effects and save time for tuning parameters. A remaining challenge before aDBS comes into(More)
The objective of this observational study is to report clinical and instrumental results obtained in 23 chronic migraine sufferers treated with transcutaneous neurostimulation with the Cefaly(®) device. The electrom yography (EMG) parameters of the patients monitored before and during neurostimulation with the Cefaly(®) device showed a significant increase(More)
OBJECTIVE Adaptive deep brain stimulation (aDBS) controlled by local field potentials (LFPs) is considered a promising treatment for advanced Parkinson's disease (PD). The clinical research investigating aDBS functioning is performed using external deep brain stimulation (DBS) systems that require LFP recording through the temporary externalization of DBS(More)
1. The diversity of cellular targets of direct current stimulation including somas, dendrites, and axon terminals, determine the modulation of synaptic efficacy. 2. Axon terminals of cortical pyramidal neurons are 2-3 times more susceptible to polarization than somas. 3. Direct current stimulation in humans results in current flow dominantly parallel to the(More)