Matthijs C. van Eede

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In fixed mouse brain magnetic resonance images, a high prevalence of fixation artifacts have been observed. Of more than 1700 images of fixed brains acquired at our laboratory, fixation artifacts were present in approximately 30%. In this study, two of these artifacts are described and their causes are identified. A hyperintense rim around the brain is(More)
The ability to visualize behaviourally evoked neural activity patterns across the rodent brain is essential for understanding the distributed brain networks mediating particular behaviours. However, current imaging methods are limited in their spatial resolution and/or ability to obtain brain-wide coverage of functional activity. Here, we describe a new(More)
Nonlinear registration algorithms provide a way to estimate structural (brain) differences based on magnetic resonance images. Their ability to align images of different individuals and across modalities has been well-researched, but the bounds of their sensitivity with respect to the recovery of salient morphological differences between groups are unclear.(More)
Using neuroimaging technologies to elucidate the relationship between genotype and phenotype and brain and behavior will be a key contribution to biomedical research in the twenty-first century. Among the many methods for analyzing neuroimaging data, image registration deserves particular attention due to its wide range of applications. Finding strategies(More)
References: [1] E.J. Slow, et al, “Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.,” Hum Mol Genet, vol. 12, 2003, p. 1555―67. [2] J.M. Van Raamsdonk, et al, “Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.,” Hum Mol Genet, vol. 14, 2005, p. 3823―35. [3](More)
The way in which brain structures express different morphologies is not fully understood. Here we investigate variability in brain anatomy using ex vivo MRI of three common laboratory mouse strains: in two inbred strains (C57BL/6 and 129S6) and one outbred strain (CD-1). We use Generalised Procrustes Analysis (GPA) to estimate modes of anatomical(More)
After more than a century of research, the mouse remains the goldstandard model system, for it recapitulates human development and disease and is quickly and highly tractable to genetic manipulations. Fundamental to the power and success of using amousemodel is the ability to stage embryonic mouse development accurately. Past staging systems were limited by(More)
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