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OBJECTIVE To evaluate the occurrence, treatment, and outcome of subdural empyema complicating community-acquired bacterial meningitis in adults. METHODS Case series from a prospective nationwide cohort study from Dutch hospitals from 2006 to 2011. RESULTS Subdural empyema was diagnosed in 28 of 1,034 episodes (2.7%), and was present on admission in 10(More)
BACKGROUND Inflammasomes are multi-protein intracellular signaling complexes that have recently been hypothesized to play a role in the regulation of the inflammation response. We studied associations between inflammasome-associated cytokines IL-1β and IL-18 in cerebrospinal fluid (CSF) of patients with bacterial meningitis and clinical outcome, and(More)
Bacterial meningitis kills or maims about a fifth of people with the disease. Early antibiotic treatment improves outcomes, but the effectiveness of widely available antibiotics is threatened by global emergence of multidrug-resistant bacteria. New antibiotics, such as fluoroquinolones, could have a role in these circumstances, but clinical data to support(More)
OBJECTIVE To evaluate the occurrence, treatment, and outcome of hydrocephalus complicating community-acquired bacterial meningitis in adults. METHODS Case series from a prospective nationwide cohort study from Dutch hospitals from 2006 to 2009. RESULTS Hydrocephalus was diagnosed in 26 of 577 episodes (5%) and was classified as communicating(More)
BACKGROUND In this nationwide prospective cohort study, we evaluated the implementation of adjunctive dexamethasone therapy in Dutch adults with pneumococcal meningitis. METHODS From March 2006 through January 2009, all Dutch patients over 16 years old with community-acquired pneumococcal meningitis were prospectively evaluated. Outcome was classified as(More)
BACKGROUND In adults with acute stroke, infections occur commonly and are associated with an unfavourable functional outcome. In the Preventive Antibiotics in Stroke Study (PASS) we aimed to establish whether or not preventive antimicrobial therapy with a third-generation cephalosporin, ceftriaxone, improves functional outcome in patients with acute stroke.(More)
BACKGROUND To evaluate clinical features and prognostic factors of cerebral infarctions in adults with community-acquired bacterial meningitis. METHOD An observational cross-sectional study, including 696 patients of whom 174 had cerebral infarction, from a prospective nationwide cohort of community-acquired bacterial meningitis (period, 1998-2002),(More)
Rapid diagnosis and treatment of acute community-acquired bacterial meningitis reduces mortality and neurological sequelae, but can be delayed by atypical presentation, assessment of lumbar puncture safety, and poor sensitivity of standard diagnostic microbiology. Thus, diagnostic dilemmas are common in patients with suspected acute community-acquired(More)
E-infrastructure projects such as CLARIN do not only make research data available to the scientific community, but also deliver a growing number of web services. While the standard methods for deploying web services using dedicated (virtual) server may suffice in many circumstances, CLARIN centers are also faced with a growing number of services that are(More)