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Induction and maintenance of peripheral tolerance are important mechanisms to maintain the balance of the immune system. In addition to the deletion of T cells and their failure to respond in certain circumstances, active suppression mediated by T cells or T-cell factors has been proposed as a mechanism for maintaining peripheral tolerance. However, the(More)
The p53 family member TAp73 is a transcription factor that plays a key role in many biological processes, including neuronal development. In particular, we have shown that p73 drives the expression of miR-34a, but not miR-34b and c, in mouse cortical neurons. miR-34a in turn modulates the expression of synaptic targets including synaptotagmin-1 and(More)
In vivo studies have demonstrated that p63 plays complex and pivotal roles in pluristratified squamous epithelial development, but its precise function and the nature of the isoform involved remain controversial. Here, we investigate the role of p63 in epithelial differentiation, using an in vitro ES cell model that mimics the early embryonic steps of(More)
For more than a week prior to the emergence of a hind limb, a steady electric current is driven out of the ventrolateral flank in the immature axolotl, returning through the integument in adjacent regions of the body. A marked peak in the density of this outcurrent could be observed over the exact area of hind limb formation 4 to 6 days prior to its(More)
Embryonic stem (ES) cell lines can be expanded indefinitely in culture while maintaining their potential to differentiate into any cell type. During embryonic development, the skin forms as a result of reciprocal interactions between mesoderm and ectoderm. Here, we report the in vitro differentiation and enrichment of keratinocytes from murine ES cells(More)
A radioautographic method was used to locate specific binding sites for biologically active iodinated calcitonin in rats. The results show that the subfornical organ of the brain, a suspected water regulating organ, is a specific target for calcitonin. The hormone predominantly binds to processes of tanycytes, suggesting that these ependymal cells play an(More)
We have compared the anatomy of immature axolotl integument from limb-forming regions with adjacent non-limb-forming regions of the flank, concentrating on the earliest stages of limb bud development. We have extended these observations to include prominent buds just prior to their differentiation. At the ultrastructural level, we note striking differences(More)
An in vivo binding assay using radioautography was employed to visualize calcitonin receptors in rat tissues. At 2 min after intravenous injection of biologically active 125I-salmon calcitonin, free hormone was separated from bound hormone by intracardiac perfusion with lactated Ringer's followed by fixation with 2.5% glutaraldehyde. Various tissues were(More)
Osteoimmunology is an interdisciplinary research field dedicated to the study of the crosstalk between the immune and bone systems. CD4(+) T cells are central players in this crosstalk. There is an emerging understanding that CD4(+) T cells play an important role in the bone marrow (BM) under physiological and pathological conditions and modulate the(More)
Background Human induced pluripotent stem cells (huiPS) are produced by in vitro reprogrammation of somatic cells. They offer new perspectives in cell therapy due to their ability to differentiate in any cell types. Nevertheless, used either in allotransplantation (different donor and recipient), or in autologous tranplantation (patient's derived iPS), iPS(More)
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