Matthieu Pichené

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The effects of isoprenaline on the induction of supraventricular tachycardia by programmed stimulation were studied in 67 patients to see whether they correlated with spontaneous catecholamine mediated symptoms during exercise testing and Holter monitoring. Thirty seven control patients (group 1) did not have spontaneous arrhythmias either during exercise(More)
Modeling and analysis of the dynamics of biological systems while accounting for single cell fluctuations is important. In particular, Bertaux [1] considered an improved hybrid stochastic-deterministic model of TRAIL induced apoptosis. TRAIL is a protein that is known to induce apoptosis in cancer cells and hence has been a target for several(More)
STUDY OBJECTIVE To determine the spontaneous changes in volumetric indices of right ventricular function assessed by thermodilution. DESIGN The study involved measurements of inter- and intraindividual variation of right ventricular function in human subjects at rest and at two different levels of low load supine bicycle exercise. SUBJECTS The subjects(More)
According to the literature and our experience, une expose our conception and our methodology of taking in charge patients after acute myocardial infarction. It is important to evaluate risks based on clinical data and exercise tests. Cardiac rehabilitation is taught of as a number of measures acting on the physical, the psychiatric and the(More)
Late potentials are an index of gravity following myocardial infarction, but there has been little investigation of the effects of fibrinolysis on their incidence. Eighty-two consecutive patients (68 men, 14 women, group men age = 55 +/- 8 years) admitted presenting with a primary infarction and who had received fibrinolytic treatment within the first four(More)
The authors report a study conducted in 167 cases of primary bronchial carcinoma, in which 6 tumour markers were assayed: carcinoembryonic antigen, alpha-1-foetoprotein, ACTH, parathormone, thyrocalcitonin, and beta-HCG. The statistical analysis of their results suggests that these markers are of limited value in routine practice. They discuss the(More)
An isoproterenol test was performed in 69 patients during electrophysiological investigation to assess its diagnostic value in adrenergic supraventricular or ventricular tachycardia. Sixteen control subjects had no symptoms on exercise and routine exercise stress testing did not trigger any hyperexcitability. Sixteen patients had reproducible documented(More)
Motivation Quantitative models are increasingly used in systems biology. Usually, these quantitative models involve many molecular species and their associated reactions. When simulating a tissue with thousands of cells, using these large models becomes computationally and time limiting. Results In this paper, we propose to construct abstractions using(More)
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