Matthieu Le Dorze

Learn More
© 2016 All authors. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the(More)
Despite our increasing ability to support vital organs and resuscitate patients, the morbidity and mortality of acute kidney injury (AKI) remain high in the intensive care unit (ICU). The ability to predict the occurrence of AKI is crucial for the development of preventive strategies. Early diagnosis of AKI requires markers that are sensitive and easily(More)
Inappropriate antibiotic therapy in ventilator-associated pneumonia (VAP) is associated with increased mortality. Using broad-spectrum antibiotics for 48 h until the results of conventional cultures and antimicrobial susceptibility testing (AST) are available, may promote the emergence of drug-resistant bacteria. Performing AST directly on clinical(More)
INTRODUCTION Septic shock is one of the most frequent causes of admission to the intensive care unit (ICU) and is associated with a poor prognosis. Early and late death in septic shock should be distinguished because they may involve different underlying mechanisms. In various conditions, the neutrophil-to-lymphocyte count ratio (NLCR) has been described as(More)
BACKGROUND The choice of empirical antimicrobial therapy for pneumonia in intensive care unit (ICU) is a challenge, since pneumonia is often related to multidrug-resistant pathogens, particularly extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E). To prevent the overuse of broad-spectrum antimicrobial therapy, the main objective of this(More)
group. On the contrary, nondepolarising muscle relaxants carry a risk of exaggerated muscle relaxant response, as was the case in our patient history. This is very well illustrated by Dallman, who reported recurarisation after a well conducted rocuronium antagonism by prostigmine. Franco-Hernández et al. reported the use of sugammadex in two cases because(More)
PURPOSE OF REVIEW Alterations of the renal microcirculation can promote the development of acute kidney injury through the interlinked occurrence of renal hypoxia and activation of inflammatory pathways. This review focuses on the recent advances in this area, and discusses the possible therapeutic interventions that might be derived from these insights. (More)
Introduction Two major immuno-inflammatory phases are well documented during sepsis: an early active inflammatory phase regulated followed by a deactivated inflammatory phase leading to immunosuppression. Innate immunity, such as monocyte HLA-DR expression (mHLA-DR), has been shown constantly and rapidly decreased. Adaptive immunity modifications have been(More)
BACKGROUND AND AIMS Cardiac output (CO) monitoring and goal-directed therapy during major abdominal surgery is currently used to decrease postoperative complications. However, few monitors are currently available for pediatric patients. Nicom(®) is a noninvasive CO monitoring technique based on the bioreactance principle (analysis of frequency variations of(More)
  • 1