Matthias van Durme

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A plethora of diverse programmed cell death (PCD) processes has been described in living organisms. In animals and plants, different forms of PCD play crucial roles in development, immunity, and responses to the environment. While the molecular control of some animal PCD forms such as apoptosis is known in great detail, we still know comparatively little(More)
During plant development various forms of programmed cell death (PCD) are implemented by a number of cell types as inherent part of their differentiation programmes. Differentiation-induced developmental PCD is gradually prepared in concert with the other cell differentiation processes. As precocious or delayed PCD can have detrimental consequences for(More)
Programmed cell death (PCD) is a collective term for diverse processes causing an actively induced, tightly controlled cellular suicide. PCD has a multitude of functions in the development and health of multicellular organisms. In comparison to intensively studied forms of animal PCD such as apoptosis, our knowledge of the regulation of PCD in plants(More)
We distinguish two main categories in the speech decoding strategies: those based on feature extraction and those based on time information of the filtered incoming signal. In the first group only those electrode pairs corresponding to the localisation of the four or more, maximum spectral peaks or the formants of the speech signal are stimulated. The(More)
Cytosine methylation is a key epigenetic mark in many organisms, important for both transcriptional control and genome integrity. While relatively stable during somatic growth, DNA methylation is reprogrammed genome-wide during mammalian reproduction. Reprogramming is essential for zygotic totipotency and to prevent transgenerational inheritance of(More)
A speech processor for simulation of preprocessed speech in cochlear implantation has been developed. An acoustic simulation of spectrally reduced speech was presented to 169 normally hearing subjects. Several perceptual tests with 9 different filter conditions were carried out. The intelligibility of sentences and the discrimination of phonemes in nonsense(More)
To produce seeds, flowering plants need to specify somatic cells to undergo meiosis. Here, we reveal a regulatory cascade that controls the entry into meiosis starting with a group of redundantly acting cyclin-dependent kinase (CDK) inhibitors of the KIP-RELATED PROTEIN (KRP) class. KRPs function by restricting CDKA;1-dependent inactivation of the(More)
In order to find the best stimulus parameters for the processing of a speech signal for cochlear implant applications, a speech processor was developed. The information which can be transmitted by means of an eight channel implant is simulated. The results indicate that identification and forced choice discrimination of (CV) and (VC) syllables is possible.(More)
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