Matthias Wiemann

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The Karnofsky Performance Status Scale (KPS) is widely used to quantify the functional status of cancer patients. However, limited data exist documenting its reliability and validity. The KPS is used in the National Hospice Study (NHS) as both a study eligibility criterion and an outcome measure. As part of intensive training, interviewers were instructed(More)
The route of infection of two endonucleobiotic bacteria in Paramecium caudatum was investigated with the electron microscope. The bacterium Holospora elegans specifically infects the micronucleus, whereas Holospora obtusa infects the macronucleus. The infectious forms of both bacteria are ingested by the prospective host cell into a phagosome. The bacteria(More)
The development of the bacterium Holospora obtusa, which infects the macronucleus of Paramecium caudatum, was investigated in the course of a new infection from the infectious form into the reproductive form and vice versa. In parallel with a complete structural reorganization of the bacterium, the protein pattern changed gradually in this development.(More)
The endonucleobiotic bacterium Holospora elegans inhabits the micronucleus of Paramecium caudatum. In this paper the release of the infectious form (IF) of H. elegans from its host is described. During the anaphase of the micronuclear division most of the IFs remain within the connecting piece which, therefore, may become enormously distended. In the course(More)
BACKGROUND Child abuse is a worldwide scourge. One of its most devastating manifestations is non-accidental head injury (NAHI). METHODS This is a retrospective chart review of children presenting to the Red Cross Children's Hospital trauma unit with a diagnosis of NAHI over a 3-year period. RESULTS Sixty-eight children were included in the study and 2(More)
Little systematic research has been reported on analgesic use in terminal cancer patients. This paper presents data from the National Hospice Study on the use of analgesics by a sample of terminal cancer patients served in home based and hospital based hospice programs as well as conventional oncological settings. Patients in hospital based hospice programs(More)
With the help of monoclonal antibodies (MAbs) we investigated the occurrence of six polypeptides throughout parts of the life cycle of Holospora obtusa, a bacterium infecting the macronucleus of the ciliate Paramecium caudatum. The polypeptides of interest formed major bands in the protein pattern of the infectious form (IF) of H. obtusa. All MAbs used(More)
Choosing the right test cases is an important task in software development due to high costs of software testing as well as the significance of software failures. Therefore, evaluating the quality of test techniques and test suites may help improving test results. Benchmarking has been successfully applied to various domains such as database performance.(More)