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We consider an efficient approximation of Bühlmann & Yu's L 2 Boosting algorithm with component-wise smoothing splines. Smoothing spline base-learners are replaced by P-spline base-learners which yield similar prediction errors but are more advantageous from a computational point of view. In particular, we give a detailed analysis on the effect of various(More)
We describe version 2.0 of the R add-on package mboost. The package implements boosting for optimizing general risk functions using component-wise (penalized) least squares estimates or regression trees as base-learners for fitting generalized linear, additive and interaction models to potentially high-dimensional data. 1. Overview The R add-on package(More)
BACKGROUND When boosting algorithms are used for building survival models from high-dimensional data, it is common to fit a Cox proportional hazards model or to use least squares techniques for fitting semiparametric accelerated failure time models. There are cases, however, where fitting a fully parametric accelerated failure time model is a good(More)
The business of content providers is being threatened by technology advances in hardware, software and IP-networks such as the Internet or peer-to-peer file sharing systems. The result is an increasing amount of illegal copies available on-line as well as off-line.With the emergence of Digital Rights Management Systems (DRMS), the media and entertainment(More)
BACKGROUND A main challenge for targeting chronic kidney disease (CKD) is the heterogeneity of its causes, co-morbidities and outcomes. Patients under nephrological care represent an important reference population, but knowledge about their characteristics is limited. METHODS We enrolled 5217 carefully phenotyped patients with moderate CKD [estimated(More)
BACKGROUND Treatment of central nervous system relapse in adult acute lymphoblastic leukemia is a challenge and outcome is poor. Liposomal cytarabine has a prolonged half-life and, given intrathecally, has produced high response rates in patients with central nervous system relapse of non-Hodgkin's lymphoma. The aim of this study was to evaluate the(More)
PURPOSE To analyze and model visual acuity (VA) in geographic atrophy (GA) secondary to age-related macular degeneration (AMD). METHODS The course of VA was analyzed using Turnbull's estimator in 226 eyes with uni- or bilateral GA due to AMD (151 patients; mean age 74.0 ± 7.6 years; mean follow-up time 33.4 ± 23.4 months) from the natural history FAM(More)
BACKGROUND Chronic kidney disease (CKD) is increasingly recognized as a global health problem. The conditions leading to CKD, the health impact of CKD and the prognosis differ markedly between affected individuals. In particular, renal failure and cardiovascular mortality are competing risks for CKD patients. Opportunities for targeted intervention are very(More)