Matthias Mueller

Bernd Kinzel4
Martin Blaimer3
4Bernd Kinzel
3Martin Blaimer
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  • Martin C. Herzig, Carine Kolly, Elke Persohn, Diethilde Theil, Tatjana Schweizer, Thomas Hafner +15 others
  • 2011
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's disease (PD), but the underlying pathophysiological mechanisms and the normal function of this large multidomain protein remain speculative. To address the role of this protein in vivo, we generated three different LRRK2 mutant mouse lines. Mice completely lacking the LRRK2(More)
  • Valérie Risson, Laetitia Mazelin, Mila Roceri, Hervé Sanchez, Vincent Moncollin, Claudine Corneloup +22 others
  • 2009
Mammalian target of rapamycin (mTOR) is a key regulator of cell growth that associates with raptor and rictor to form the mTOR complex 1 (mTORC1) and mTORC2, respectively. Raptor is required for oxidative muscle integrity, whereas rictor is dispensable. In this study, we show that muscle-specific inactivation of mTOR leads to severe myopathy, resulting in(More)
In this article it is shown that GRAPPA reconstruction can be reformulated as a matrix operator, similar to ladder or propagator operators used in quantum mechanics, that shifts data in k-space. Using this formalism, it is shown that there exists an infinitesimal GRAPPA operator that shifts data in k-space by arbitrarily small amounts. Other desired k-space(More)
When using parallel MRI (pMRI) methods in combination with three-dimensional (3D) imaging, it is beneficial to subsample the k-space along both phase-encoding directions because one can then take advantage of coil sensitivity variations along two spatial dimensions. This results in an improved reconstruction quality and therefore allows greater scan time(More)
Since the advent of highly pathogenic variants of avian influenza virus (HPAIV), the main focus of avian influenza research has been the characterization and detection of HPAIV hemagglutinin (HA) from H5 and H7 subtypes. However, due to the high mutation and reassortation rate of influenza viruses, in theory any influenza strain may acquire increased(More)
Parallel imaging has proven to be a robust solution to the problem of acquisition speed in MRI. These methods are based on extracting spatial information from an array of multiple surface coils in order to speed up image acquisition. One of the most essential elements of any parallel imaging method is the information describing the coil sensitivity(More)
  • Jan S. Tchorz, Thomas Suply, Iwona Ksiazek, Claudio Giachino, Dimitri Cloëtta, Claus-Peter Danzer +7 others
  • 2012
Generation of gain-of-function transgenic mice by targeting the Rosa26 locus has been established as an alternative to classical transgenic mice produced by pronuclear microinjection. However, targeting transgenes to the endogenous Rosa26 promoter results in moderate ubiquitous expression and is not suitable for high expression levels. Therefore, we now(More)
  • Derya R. Shimshek, Matthias Mueller, Christoph Wiessner, Tatjana Schweizer, P. Herman van der Putten
  • 2010
Background: Aggregation and misfolded a-synuclein is thought to be central in the pathogenesis of Parkinson's disease (PD). Heat-shock proteins (HSPs) that are involved in refolding and degradation processes could lower the aggregate load of a-synuclein and thus be beneficial in a-synucleinopathies.
OBJECTIVE The objective of the current study was to find a metabolic signature associated with the early manifestations of type-2 diabetes mellitus. RESEARCH DESIGN AND METHOD Modern metabolic profiling technology (MxP™ Broad Profiling) was applied to find early alterations in the plasma metabolome of type-2 diabetic patients. The results were validated(More)
The nuclear receptor liver receptor homologue-1 (LRH-1, NR5A2) is a crucial transcriptional regulator of many metabolic pathways. In addition, LRH-1 is expressed in intestinal crypt cells where it regulates the epithelial cell renewal and contributes to tumorigenesis through the induction of cell cycle proteins. We have recently identified the intestinal(More)