Matthias Meier

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We present RNA-mechanically induced trapping of molecular interactions (RNA-MITOMI), a microfluidic platform that allows integrated synthesis and functional assays for programmable RNA libraries. The interaction of a comprehensive library of RNA mutants with stem-loop-binding protein precisely defined the RNA structural and sequence features that govern(More)
Configurable hardware is becoming increasingly powerful and less expensive. This allows embedded system developers to exploit hardware parallelism in order to improve real time properties and energy efficiency. However, hardware design, even if performed using high-level hardware description languages, is error-prone and time consuming, especially when(More)
The root functions as the physical anchor of the plant and is the organ responsible for uptake of water and mineral nutrients such as nitrogen, phosphorus, sulfate and trace elements that plants acquire from the soil. If we want to develop sustainable approaches to producing high crop yield, we need to better understand how the root develops, takes up a(More)
In 1971 KEUTEL et al. described a new syndrome in two siblings presenting with peripheral pulmonary stenoses, brachytelephalangism, neural hearing loss and abnormal cartilage calcification. Recent investigations provided evidence that mutations in the gene encoding the human matrix GLA protein cause Keutel syndrome. With these new insights in the disease(More)
Assembly cloning is increasingly replacing conventional restriction enzyme and DNA-ligase-dependent cloning methods for reasons of efficiency and performance. Here, we describe AQUA (advanced quick assembly), a simple and versatile seamless assembly cloning approach. We demonstrate the applicability and versatility of AQUA Cloning in selected(More)
BACKGROUND Fractures of the long bones and femur fractures in particular are common in multiple trauma patients, but the optimal management of femur fractures in these patients is not yet resolved. Although there is a trend towards the concept of "Damage Control Orthopedics" (DCO) in the management of multiple trauma patients with long bone fractures as(More)
Hardware description languages are a promising field for the application of aspect technology. In a case study with the MB-Lite soft core CPU, which is an open, cycle accurate re-implementation of Xilinx' Microblaze processor, we show that crosscutting concerns in hardware structures actually exist. After discussing the semantic differences between(More)
Transactional memory is regarded as a very promising technology to deal with concurrency control in future multicore and manycore systems. While a lot of software, hardware, and hybrid transactional memory implementations have been proposed and analyzed, the silver bullet still hasn't been found. The main reason is that the performance of transactional(More)
Here, we present an in silico, analytical procedure for designing and testing orthogonal DNA templates for multiplexing of the proximity ligation assay (PLA). PLA is a technology for the detection of protein interactions, post-translational modifications, and protein concentrations. To enable multiplexing of the PLA, the target information of antibodies was(More)