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OBJECTIVE To assess the value of spectroscopic and perfusion MRI for glioma grading and for distinguishing glioblastomas from metastases and from CNS lymphomas. METHODS The authors examined 79 consecutive patients with first detection of a brain neoplasm on nonenhanced CT scans and no therapy prior to evaluation. Spectroscopic MRI; arterial spin-labeling(More)
We describe the optimal high-level postprocessing of single-voxel (1)H magnetic resonance spectra and assess the benefits and limitations of automated methods as diagnostic aids in the detection of recurrent brain tumor. In a previous clinical study, 90 long-echo-time single-voxel spectra were obtained from 52 patients and classified during follow-up(More)
We evaluated the value of magnetic resonance imaging (MRI) and the additional benefit of proton MR spectroscopic imaging (1H SI) in patients with a new suspicious lesion after fractionated stereotactic radiotherapy (FSRT) of a glioma. Thirty-four patients with histologically proven astrocytoma WHO II-IV after treatment by FSRT and a new suspect lesion in(More)
PURPOSE To describe our first experiences with a recently introduced 3T system for T2-weighted isotropic 3D whole-spine imaging. MATERIAL AND METHODS Magnetic resonance imaging of the whole spine was performed by implementing an isotropic 3D fast spin-echo sequence with variable flip-angle refocusing pulses at 3T and 1.5T. Signal-to-noise ratio (SNR) was(More)
Since antineoplastic activity varies, sensitive methods for individual assessment of efficacy are needed. We demonstrate the clinical value of MR spectroscopy in monitoring chemotherapy in a patient with recurrent glioma after stereotactic radiotherapy. Diagnostic imaging before and after chemotherapy included contrast-enhanced MRI, single-voxel proton MR(More)
Magnetic resonance spectroscopic images (MRSI) carry spatially resolved information about the in vivo metabolism, however, their evaluation is difficult. Problems arise especially from artifacts and noise, yielding non-evaluable signals in many voxels. We propose a two-step approach to the processing of MRSI. In the first step a non-linear classi-fier is(More)
PURPOSE In patients with a neuroendocrine tumour (NET), the extent of disease strongly influences the outcome and multidisciplinary therapeutic management. Thus, systematic analysis of the diagnostic performance of the existing staging modalities is necessary. The aim of this study was to compare the diagnostic performance of 2 whole-body imaging(More)