Matthias Krams

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BACKGROUND Constitutive expression and localization of antimicrobial human beta-defensin-1 (HBD-1) in human kidneys as a potential mechanism of antimicrobial defense has been previously reported. Inducible expression of human beta-defensin-2 (HBD-2) has been described in various epithelial organs but not for the urogenital tract. METHODS We investigated(More)
Telomere maintenance is a prerequisite for immortalisation, and in most malignant cells is carried out by telomerase, an enzyme that synthesis new telomeric repeats on the chromosome ends. In normal or reactive tissues with a high regenerative capacity, telomerase is regulated according to the telomere loss that occurs during proliferation. To evaluate the(More)
Severe combined immunodeficient (SCID)' mice have an autosomal recessive defect that impairs the rearrangement of antigen receptor genes in lymphoid progenitors (1). Consequently, functional lymphocytes do not develop and these animals are severely lymphopenic (2, 3). Recent results have demonstrated that human fetal lymphoid tissue or peripheral blood(More)
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