Learn More
OBJECTIVE Impaired detoxification of carcinogens found in tobacco smoke appears to increase the risk for tobacco associated cancer. The objective of this study was to investigate concomitant polymorphisms in genes encoding for various detoxification enzymes in patients with head and neck squamous cell carcinoma (HNSCC). METHODS In 187 patients with HNSCC(More)
BACKGROUND Differences in genotype and phenotype of detoxification genes could be one reason for conflicting results in studies dealing with gene polymorphisms as susceptibility factors for tobacco associated cancer. OBJECTIVES The objective of this study was to investigate gene polymorphisms of detoxification enzymes and to determine whether the enzyme(More)
2 = 0.85, while for the regional method, we apply results in τ MODIS = 1.02 τ AERONET + 0.04, R 2 = 0.92. This improved performance is maintained even for high-resolution retrieval down to 1.5 km with a regression of τ MODIS = 0.96 τ AERONET + 0.02, R 2 = 0.88. In addition, we show that this method can be extended to other urban scenes such as Mexico City(More)
11Beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) has been identified as a major detoxification enzyme of one of the most potent tobacco smoke-derived carcinogens, NNK. If not metabolized by 11beta-HSD1, activation of NNK by cytochrome p450 mono-oxidase 2D6 (CYP2D6) results in an electrophile intermediate responsible for DNA damage. Interindividual(More)
  • 1