Matthias Jentschke

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INTRODUCTION Population coverage for cervical cancer screening is an important determinant explaining differences in the incidence of cervical cancer between countries. Offering devices for self-sampling has the potential to increase participation of hard-to-reach women. METHODS A systematic review and meta-analysis were performed to evaluate the(More)
OBJECTIVES Human papillomavirus (HPV) testing is an important part of cervical cancer screening and management of women with atypical screening results. This study was conducted to evaluate the analytical and clinical performance of the Abbott RealTime High-Risk HPV assay (RealTime) in a referral population, in comparison to the Qiagen Hybrid Capture 2(More)
Self-collection of cervical samples for human papillomavirus (HPV) testing can help to raise the participation rate in cervical cancer screening among non-responders. This study was conducted to compare the analytical and clinical performance of the Abbott RealTime High-Risk HPV Test (RealTime) with the Hybrid Capture 2 assay (HC2) on self-collected(More)
To characterize the clinical presentation and outcome of patients with vaginal intraepithelial neoplasia (VAIN). Medical records of 65 women with VAIN treated between 2005 and 2012 at the colposcopy clinic of a German university hospital were retrospectively evaluated for VAIN grade, HPV status, VAIN localization, treatment method and relapse rate.(More)
OBJECTIVE To evaluate enzyme-linked immunosorbent assay (ELISA) for cyclin-dependent kinase inhibitor 2A protein (p16(INK4a) ) on self-collected cervicovaginal lavage samples as an additional triage test to identify women with high-grade cervical intraepithelial neoplasia (CIN). DESIGN Retrospective feasibility, sensitivity and specificity study. (More)
The new German S3 guideline 'Prevention of Cervical Cancer' published in 2016 is based on the latest available evidence about cervical cancer screening and treatment of cervical precancer. Large randomized controlled trials indicate that human papillomavirus (HPV)-based screening may provide better protection against cervical cancer than cytology alone(More)
Silencing of HPV oncogenes or their human host client proteins using topically applied small interfering RNA (siRNA) may be an attractive nonsurgical strategy for CIN treatment. An exploratory clinical investigation was designed to evaluate E6-AP mRNA expression levels in different stages of cervical intraepithelial neoplasia and during the menstrual cycle.(More)
AIM To evaluate the analytical and clinical effectiveness of cervicovaginal self-sampling with a dry sampling device (Evalyn Brush) for high-risk human papillomavirus (hr-HPV) testing and detection of cervical disease. METHODS The study population consisted of 101 patients from a large gynecological outpatient clinic in Shanghai referred for abnormal(More)
Evaluating the application of the sentinel lymph node dissection (SLND) in gynecological cancers among German hospitals. Between March and June 2016 an online questionnaire on SLND in gynecologic cancers was sent by email to all German gynecologic cancer centers, all university hospitals and general hospitals for which an email address was available. The(More)
Das Zervixkarzinom ist in Deutschland das dritthäufigste genitale Karzinom der Frau. Seine Therapie erfolgt adaptiert an Tumorstadium, Risiko- und individuelle Patientenfaktoren. Das Zervixkarzinom wird klinisch nach den FIGO-Stadien (FIGO: „Fédération Internationale de Gynécologie et d’Obstétrique“) eingeteilt. Hierfür erforderlich sind eine gynäkologische(More)