Learn More
The analysis of rich catalogues of genetic variation from population-based sequencing provides an opportunity to screen for functional effects. Here we report a rare variant in APOC3 (rs138326449-A, minor allele frequency ~0.25% (UK)) associated with plasma triglyceride (TG) levels (-1.43 s.d. (s.e.=0.27 per minor allele (P-value=8.0 × 10(-8))) discovered(More)
UNLABELLED High-throughput sequencing technologies survey genetic variation at genome scale and are increasingly used to study the contribution of rare and low-frequency genetic variants to human traits. As part of the Cohorts arm of the UK10K project, genetic variants called from low-read depth (average 7×) whole genome sequencing of 3621 cohort(More)
The amount of digital data that requires long-term protection of integrity, authenticity, and confidentiality grows rapidly. Examples include electronic health records, genome data, and tax data. In this paper we present the secure storage system LINCOS, which provides protection of integrity, authenticity, and confidentiality in the long-term, i.e., for an(More)
Current trends in technology, such as cloud computing, allow outsourcing the storage, backup, and archiving of data. This provides efficiency and flexibility, but also poses new risks for data security. It in particular became crucial to develop protection schemes that ensure security even in the long-term, i.e. beyond the lifetime of keys, certificates,(More)
With increasing digitization, the amount of archived data that requires long-term protection of confidentiality and integrity increases rapidly. Examples include electronic health records, genome data bases, and tax data. In this paper we present the first archiving solution that provides everlasting confidentiality and, at the same time, maintains a proof(More)
The amount of security critical data that is only available in digital form is increasing constantly. The Evidence Record Syntax Specification (ERS) achieves very efficiently important security goals: integrity, authenticity, datedness, and non-repudiation. This paper supports the trustworthiness of ERS by proving ERS secure. This is done in a model(More)
  • 1