Matthias Ganzinger

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OBJECTIVES Ambient Assisted Living (AAL) technologies are developed to enable elderly to live independently and safely. Innovative information technology (IT) can interconnect personal devices and offer suitable user interfaces. Often dedicated solutions are developed for particular projects. The aim of our research was to identify major IT challenges for(More)
In biomedical research, a variety of data like clinical, genetic, expression of coding or non-coding ribonucleic acid (RNA) transcripts, or proteomic data are processed to gain new insights into diseases and therapies. In transregional research networks, geographically distributed projects work on comparable research questions with data from different(More)
We investigated for a research network on liver cancer semantic prerequisites for successful data sharing. To support collaboration with information technology, it is important to annotate research data with metadata. Ideally, all data handled are described ontologically to allow for automated reasoning. However, a complete ontology is hard to define. As a(More)
UNLABELLED The far upstream element binding protein (FBP) and the FBP-interacting repressor (FIR) represent molecular tools for transcriptional fine tuning of target genes. Strong overexpression of FBP in human hepatocellular carcinoma (HCC) supports tumor growth and correlates with poor patient prognosis. However, the role of the transcriptional repressor(More)
OBJECTIVES In the Multiple Myeloma clinical registry at Heidelberg University Hospital, most data are extracted from discharge letters. Our aim was to analyze if it is possible to make the manual documentation process more efficient by using methods of natural language processing for multiclass classification of free-text diagnostic reports to automatically(More)
OBJECTIVE Joint data analysis is a key requirement in medical research networks. Data are available in heterogeneous formats at each network partner and their harmonization is often rather complex. The objective of our paper is to provide a generic approach for the harmonization process in research networks. We applied the process when harmonizing data from(More)
BACKGROUND One of the key components in palliative care is communication. eHealth technologies can be an effective way to support communications among participants in the process of palliative care. However, it is unclear to what extent information technology has been established in this field. OBJECTIVE Our goal was to systematically identify studies and(More)
Sharing data in biomedical research networks has great potential benefits including efficient use of resources, avoiding duplicate experiments and promoting collaboration. However, concerns from data producers about difficulties of getting proper acknowledgement for their contributions are becoming obstacles for efficient and network wide data sharing in(More)
Research data and biospecimen repositories are valuable resources for biomedical investigators. Sharing these resources has great potential benefits including efficient use of resources, avoiding duplicate experiments, gathering adequate sample sizes, and promoting collaboration. However, concerns from data producers about difficulties of getting proper(More)
Security, particularly integrity and confidentiality, is a prerequisite for using mobile ad hoc networks (MANETs) in sensitive or hostile environments. Existing MANET routing protocols, however, are commonly not designed to ensure, that only authorized nodes can join the MANET. The topology of the MANET and potential points of attack are revealed to(More)