Matthias Fröhlich

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Serotonin receptors 5-HT(1A) and 5-HT(7) are highly coexpressed in brain regions implicated in depression. However, their functional interaction has not been established. In the present study we show that 5-HT(1A) and 5-HT(7) receptors form heterodimers both in vitro and in vivo. Foerster resonance energy transfer-based assays revealed that, in addition to(More)
Voice corpora of pathological voices are generally based on high-quality audio recordings. These are supplemented with additional information describing the general recording conditions and the individual subjects. While an acoustic analysis cannot be expected to specify certain medical diagnoses it may reflect the glottal phonation conditions. Two examples(More)
The hoarseness diagram supplies a method to quantitatively describe the periodicity and the noise content of voices. It is based on four acoustic measures, three of which assess different aspects of periodicity (jitter, shimmer, mean period correlation) while one indicates the relative amount of additive noise (glottal to noise excitation ratio). The(More)
Die Bedeutung der objektivierbaren Stimmgütebeschreibung spiegelt sich im zunehmendem Einsatz akustischer Analsyemethoden in der klinischen Diagnostik und Forschung wider. Das Heiserkeits-Diagramm ermöglicht die akustische Stimmgütebeschreibung auch hochgradig gestörter Stimmen bis hin zur Aphonie. Die Objektivierbarkeit der Stimmqualitätsverbesserung bei(More)
One important perceptual attribute of voice quality is breathiness. Since breathiness is generally regarded to be caused by glottal air leakage, acoustic measures related to breathiness may be used to distinguish between different physiological phonation conditions for pathological voices. Seven “breathiness features” described in the literature plus one(More)
BACKGROUND In the severely injured who survive the early posttraumatic phase, multiple-organ failure (MOF) is the main cause of morbidity and mortality. An enhanced prediction of MOF might influence individual monitoring and therapy of severely injured patients. METHODS We performed a retrospective analysis of a nationwide prospective database, the(More)
BACKGROUND Accidental hypothermia, acidosis, and coagulopathy represent the lethal triad in severely injured patients. Therapeutic hypothermia however is commonly used in transplantations, cardiac and neurosurgical surgery, or after cardiac arrest. However, the effects of therapeutic hypothermia on the coagulation system following multiple trauma need to be(More)
Despite the high incidence and prognostic relevance of hemorrhagic shock and abdominal and blunt chest trauma in multiply injured patients, there are no animal models combining these injuries. Therefore, we established a new porcine multiple trauma model consisting of blunt chest trauma, penetrating abdominal trauma (two incisions in the right upper liver(More)
Outcome studies of lumbar disc surgery document a success rate ranging between 49% and 90%, according to the evaluation criteria used. The aim of the present study was to investigate the prognostic value of pain history and of sociodemographic, psychodiagnostic and medical factors for the long-term outcome after lumbar disc surgery. Between selection for(More)
OBJECTIVES To assess the merits of computer-aided voice analysis procedures for very irregular voices of patients after total and laser surgical partial laryngectomy, and to characterize qualitative differences in speech and voice function between these 2 groups of patients. DESIGN Cross-sectional study. SETTING University hospital in Göttingen, Germany(More)