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Das Eckpunktepapier aus dem Jahr 2007 hat wichtige Rahmenbedingungen und Ziele definiert, die als Grundlage für Strukturanforderungen und die notfallmedizinische Planung dienten. Die steigenden Anforderungen an die notfallmedizinische Versorgung der Bevölkerung machen es erforderlich, das Eckpunktepapier 2007 zu aktualisieren und zu erweitern. Das Ergebnis(More)
Resuscitation of the brain after cardiac arrest requires homogeneous blood recirculation which, however, may be impaired by low reperfusion pressure, intravascular coagulation, increased blood viscosity and endothelial cell swelling. Intravascular volume expansion induced by intravenous infusion of a small volume of hypertonic solution has previously been(More)
About 75000 people suffer from sudden cardiac arrest in Germany every year. 47% of all out-of-hospital cardiac arrests (OHCA) in Germany are bystander witnessed, but in only 16.1% is bystander-initiated CPR undertaken. In comparison to other countries, Germany is in the last third of bystander-initiated CPR activities. But bystander CPR is one of the most(More)
Heterologous expression in yeast cells revealed that NtAQP1, a member of the so-called PIP1 aquaporin subfamily, did not display increased water transport activity in comparison with controls. Instead, an increased CO(2)-triggered intracellular acidification was observed. NtPIP2;1, which belongs to the PIP2 subfamily of plant aquaporins, behaved as a true(More)
OBJECTIVE Successful resuscitation of the brain requires complete microcirculatory reperfusion, which, however, may be impaired by activation of blood coagulation after cardiac arrest. The study addresses the question of whether postischemic thrombolysis is effective in reducing cerebral no-reflow phenomenon. DESIGN 14 adult normothermic cats were(More)
Adult normothermic cats were submitted to 1-h complete cerebrocirculatory arrest by intrathoracic occlusion of the internal mammary, the innominate, and the subclavian arteries in combination with pharmacologically induced hypotension. After ischemia, recirculation was initiated at different blood pressure levels to manipulate the postischemia resuscitation(More)
UNLABELLED Mechanical ventilation with high tidal volumes (V(T)) and zero or low positive end-expiratory pressure increased mediator release to inflammatory stimuli or acute lung injury. We studied whether mechanical ventilation modifies the inflammatory responses during major thoracic or abdominal surgery. Sixty-four patients undergoing elective(More)
Due to the fact that most plants are immobile, a rapid response of physiological processes to changing environmental conditions is essential for their survival. Thus, in comparison to many other organisms, plants might need a more sophisticated tuning of water balance. Among others, this is reflected by the comparable large amount of aquaporin genes in(More)
Shape and physico-chemical properties of the scissile fatty acid binding sites of six lipases and two serine esterases were analyzed and compared in order to understand the molecular basis of substrate specificity. All eight serine esterases and lipases have similar architecture and catalytic mechanism of ester hydrolysis, but different substrate(More)
Though most dermatoses are not life-threatening, skin diseases play an important role in intensive care medicine. Skin findings in intensive care patients may reflect the underlying disease or be complications of intensive medical care. Most important are drug reactions, infections, bacterial toxin reactions, erythroderma, ANCA-positive vasculitides (such(More)