Matthias Bossard

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Antibodies that stimulate the immune system by targeting inhibitory T cell receptors were successfully introduced into oncological practice and are capable to overcome tumor-induced immune evasion. In particular, targeting of the inhibitory receptors CTLA-4 and PD-1 or its ligand PD-L1 have been shown to be beneficial for patients with melanoma, renal cell(More)
INTRODUCTION Left atrial (LA) enlargement is an important risk factor for incident stroke and a key determinant for the success of rhythm control strategies in patients with atrial fibrillation (AF). However, factors associated with LA volume in AF patients remain poorly understood. METHODS Patients with paroxysmal or persistent AF were enrolled in this(More)
BACKGROUND Treatment to restore sinus rhythm among patients with atrial fibrillation (AF) has limited long-term success rates. Gene expression profiling may provide new insights into AF pathophysiology. OBJECTIVE To identify biomarkers and improve our understanding of AF pathophysiology by comparing whole blood gene expression before and after electrical(More)
  • Cardiovascular Research, Institute, +15 authors David Conen
  • 2014
E levated blood pressure (BP) and dysglycemia are highly prevalent on a global basis 1–3 and are 2 of the most important cardiovascular risk factors. 4–8 Both entities are strongly correlated, 9 and the combined occurrence substantially increases cardiovascular risk in affected individuals. Although various factors, including hyperinsulinemia, volume(More)
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