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Elevated in vivo markers of presynaptic striatal dopamine activity have been a consistent finding in schizophrenia, and include a large effect size elevation in dopamine synthesis capacity. However, it is not known if the dopaminergic dysfunction is limited to the striatal terminals of dopamine neurons, or is also evident in the dopamine neuron cell bodies,(More)
The ability to make advantageous choices among outcomes that differ in magnitude, probability, and delay until their arrival is critical for optimal survival and well-being across the lifespan. Aged individuals are often characterized as less impulsive in their choices than their young adult counterparts, demonstrating an increased ability to forgo(More)
6 Recent advances in technology have produced a significant increase in the avail-7 ability of free sensor data over the Internet. With affordable weather monitoring 8 stations now available to individual meteorology enthusiasts, a reservoir of real 9 time data such as temperature, rainfall and wind speed can now be obtained for 10 most of the world.(More)
We describe the application of assumption-based argumenta-tion (ABA) to a domain of medical knowledge derived from clinical trials of drugs for breast cancer. We adapt an algorithm for calculating the admissible semantics for ABA frameworks to take account of preferences and describe a prototype implementation which uses variant-based parallel computation(More)
Exposure to psychostimulant drugs of abuse such as amphetamine can result in long-lasting "sensitization" of reward-directed behavior, such that subjects display enhancements in behavior directed by and toward rewards and reward-predictive cues (i.e. "incentive sensitization"). The purpose of these experiments was to determine the degree to which such(More)
Two approaches to breast cancer prognosis: • Argumentation: reasoning is clear but hard to weigh up • Statistical: reliable conclusions, unclear chain of inference a combination might offer clarity and reliability Two approaches to combining: • Integrated framework: start from scratch • Modular framework: off the shelf, simpler, customisable Data +(More)
We introduce a novel Ontology-based Argumentation Framework (OAF) that links a logic-based argumentation formalism and description logic ontologies. We show how these two formalisms can be tightly coupled by observing a few simple restrictions, and provides features not available in either formalism alone. Our work is evaluated in a large case study on(More)
Web-based distributed modelling architectures are gaining increasing recognition as potentially useful tools to build holistic environmental models, combining individual components in complex workflows. However, existing web-based modelling frameworks currently offer no support for managing uncertainty. On the other hand, the rich array of modelling(More)
Evidence-based decision making is becoming increasingly important in healthcare. Much valuable evidence is in the form of the results from clinical trials that compare the relative merits of treatments. For this, in previous papers, we have proposed a general framework for representing and synthesizing knowledge from clinical trials involving the same(More)
OBJECTIVES To quantify mortality associated with sepsis in the whole population of England. DESIGN Descriptive statistics of multiple cause of death data. SETTING England between 2001 and 2010. PARTICIPANTS All people whose death was registered in England between 2001 and 2010 and whose certificate contained a sepsis-associated International(More)