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We describe a largely unbiased method for rapid and large-scale proteome analysis by multidimensional liquid chromatography, tandem mass spectrometry, and database searching by the SEQUEST algorithm, named multidimensional protein identification technology (MudPIT). MudPIT was applied to the proteome of the Saccharomyces cerevisiae strain BJ5460 grown to(More)
Presynaptic nicotinic acetylcholine receptors (nAChRs) on striatal synaptosomes stimulate dopamine release. Partial inhibition by the alpha3beta2-selective alpha-conotoxin-MII indicates heterogeneity of presynaptic nAChRs on dopamine terminals. We have used this alpha-conotoxin and UB-165, a novel hybrid of epibatidine and anatoxin-a, to address the(More)
—Diode lasers have many useful properties and have found a variety of uses including CD and DVD players, barcode scanners, laser surgery, water purification, quantum-key cryptography , spectroscopic sensing, etc. Nevertheless, their intrinsic linewidth or the precision of their emitted wavelengths, is not good enough for many cutting-edge applications such(More)
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