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Theta Rhythms Coordinate Hippocampal–Prefrontal Interactions in a Spatial Memory Task
Using simultaneous tetrode recordings from CA1 of the rat hippocampus and medial prefrontal cortex, it is shown that correlated firing in the two structures is selectively enhanced during behavior that recruits spatial working memory, allowing the integration of hippocampal spatial information into a broader, decision-making network.
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
Impairments in functional synaptic plasticity may underlie some of the cognitive deficits in these mice and, possibly, in Alzheimer's patients.
Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network
Evidence is provided that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation, by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-d-aspartate (NMDA) receptor NR1 in dentates gyrus granule Cells.
Phase precession of medial prefrontal cortical activity relative to the hippocampal theta rhythm
MPFC phase precession was most robust during behavioral epochs known to be associated with enhanced theta‐frequency coordination of CA1 and mPFC activities, and implies a more global role for this phenomenon during theta rhythm‐mediated coordination of neural activity.
Quantifying phase-amplitude coupling in neuronal network oscillations.
Estimating linear dependence between nonstationary time series using the locally stationary wavelet model
Large volumes of neuroscience data comprise multiple, nonstationary electrophysiological or neuroimaging time series recorded from different brain regions. Accurately estimating the dependence
Updating hippocampal representations: CA2 joins the circuit
This Review highlights recently discovered anatomical and physiological features that are likely to necessitate updates to the hippocampal circuit diagram, particularly by incorporating the oft-neglected CA2 region.
Back to front: cerebellar connections and interactions with the prefrontal cortex
The results demonstrate the presence of a cerebello-prefrontal pathway in rat and reveal behaviorally dependent coordinated network activity between the two structures, which could facilitate transfer of sensorimotor information into ongoing neocortical processing during goal directed behaviors.