Matthew W. Mason

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The relative importance that certain strain features, including mode (e.g., tension vs. compression) and magnitude, have in affecting adaptive bone remodeling seen in normal skeletally mature bones remains controversial. The equine radius is used as a model because in vivo strain data show that the mid-to-proximal diaphysis receives a consistent history of(More)
BACKGROUND Functionally induced strains provide epigenetic signaling for bone modeling and remodeling activities. Strain gauge documentation of the equine third metacarpal reveals a neutral axis passing through the craniolateral cortex, resulting in a narrow band of cortex loaded predominantly in tension, with the remainder of the cortex experiencing a wide(More)
BACKGROUND Examination of a simple skeletal cantilevered beam-like bone (artiodactyl calcaneus) suggests that regional differences in strain magnitude and mode (tension vs. compression) reflect regional adaptation in the structural/material organization of bone. The artiodactyl (e.g., sheep and deer) calcaneus has a predominant loading condition typified by(More)
One hundred thirty patients with severe aplastic anemia were conditioned with cyclophosphamide for transplantation of marrow from HLA-identical siblings. The patients were selected for the present analysis according to the criterion of sustained marrow engraftment. Of the 130 patients, 97 are now alive between 1.4 and 11 years (median, 5) after(More)
BACKGROUND It has been hypothesized that bone has the capacity to accommodate regional differences in tension and compression strain mode and/or magnitude by altering its osteonal microstructure. We examined a simple cantilevered bone to determine whether regional differences in particular strain-related features are reflected in the microstructural(More)
The artiodactyl (mule deer) calcaneus was examined for structural and material features that represent regional differences in cortical bone modeling and remodeling activities. Cortical thickness, resorption and formation surfaces, mineral content (percent ash), and microstructure were quantified between and within skeletally immature and mature bones.(More)
Coronary heart disease incidence during 1958-1974, in a cohort of Hiroshima and Nagasaki residents, was found to relate significantly (p = 0.01) to total leukocyte count, taken an average of two years earlier. Relative risks, as a function of leukocyte count, did not appear to depend on sex or cigarette smoking status, but may be larger for subjects less(More)
Data on Hiroshima and Nagasaki A-bomb survivors are used to investigate, for each city, possible circular asymmetry in cancer mortality around the hypocenter. Using the Cox regression method and controlling for age ATB, sex, followup year, distance from the hypocenter, and type of shielding, it is found that in Hiroshima cancer mortality was significantly(More)
Elevated total leukocyte count in a biennial examination period is shown to be a significant (p = 0.001) predictor of cerebral infarction (CI) incidence in the subsequent 2 yr examination period, in a large Japanese cohort study. This association is not explainable on the basis of corresponding age, sex or blood pressure levels. The extent to which the(More)