Matthew Turpin

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GR159897 ((R)-1-[2-(5-fluoro-1H-indol-3-yl)ethyl]-4-methoxy-4- [(phenylsulfinyl)methyl]piperidine) is a novel, highly potent and selective non-peptide antagonist at tachykinin NK2 receptors. GR159897 inhibited binding of the NK2 receptor antagonist radioligand [3H]cyclohexylcarbonyl-Gly-Ala-(D)Trp-Phe-NMe2 ([3H]GR100679) to human ileum NK2 receptors(More)
In this work we consider the problem of controlling a team of microaerial vehicles moving quickly through a three-dimensional environment while maintaining a tight formation. The formation is specified by a shape matrix that prescribes the relative separations and bearings between the robots. Each robot plans its trajectory independently based on its local(More)
We address formation control for a team of quadrotors in which the robots follow a specified group trajectory while safely changing the shape of the formation according to specifications. The formation is prescribed by shape vectors which dictate the relative separations and bearings between the robots, while the group trajectory is specified as the desired(More)
Homozygotes for a BalI polymorphism resulting in the Ser9Gly mutation in the human dopamine D3 receptor gene are suggested to display a twofold higher risk of schizophrenia. The cDNAs for this mutant and the wildtype receptor were introduced into the pSFV1C vector and recombinant Semliki Forest virus particles generated. CHO cells infected with SFV-D3 virus(More)
In this paper, we consider the problem of concurrent assignment and planning of trajectories (which we denote CAPT) for a team of robots. This problem involves simultaneously addressing two challenges: (1) the combinatorially complex problem of finding a suitable assignment of robots to goal locations, and (2) the generation of collision-free, time(More)
This paper considers the problem of finding optimal time parameterized trajectories for N unlabeled robots navigating through a cluttered environment to N unlabeled goal locations where success is defined as every goal being reached by any robot. We propose a complete computationally-tractable algorithm for simultaneously finding trajectories and assignment(More)
In this paper, we consider the problem of tasking large numbers of homogenous robots to move to a set of specified goal locations, addressing both the assignment and trajectory planning subproblems concurrently. This is related to the standard linear Euclidean assignment problem except that the solution to the trajectory generation subproblem must result in(More)
Nine mutants and the wild-type human dopamine D3 receptor were expressed at high levels in BHK and CHO cells using the Semliki Forest virus system and were analysed for receptor binding with several structurally different dopamine D3 ligands. The mutation His349Leu showed a significant decrease in pKi values for raclopride, dopamine and GR218231, but an(More)
The locomotor activity (LMA) response induced after infusion of selective neurokinin (NK) agonists into the cell body (A10) and a terminal region of the mesolimbic pathway of the rat was investigated. Infusion of the NK1 receptor-selective agonist, GR73632, into the ventral tegmental area (VTA: A10) or the nucleus accumbens (NAS) significantly and(More)
This paper presents a computationally tractable, resolution-complete algorithm for generating dynamically feasible trajectories for N interchangeable (identical) aerial robots navigating through cluttered known environments to M goal states. This is achieved by assigning the robots to goal states while concurrently planning the trajectories for all robots.(More)