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Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-d-aspartate Glutamate Receptors
The four N-methyl-d-aspartate (NMDA) receptor NR2 subunits (NR2A-D) have different developmental, anatomical, and functional profiles that allow them to serve different roles in normal andExpand
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Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes
Heteromeric NMDARs are composed of coagonist glycine‐binding NR1 subunits and glutamate‐binding NR2 subunits. The majority of functional NMDARs in the mammalian central nervous system (CNS) containExpand
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Structure and Function of the NMDA Receptor
1 Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synaptic transmission in the central nervous system. Based on their structural and pharmacological properties,Expand
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Mechanism of Partial Agonism at NMDA Receptors for a Conformationally Restricted Glutamate Analog
The NMDA ionotropic glutamate receptor is ubiquitous in mammalian central neurons. Because partial agonists bind to the same site as glutamate but induce less channel activation, these compoundsExpand
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The SAMPL2 blind prediction challenge: introduction and overview
TLDR
The interactions between a molecule and the aqueous environment underpin any process that occurs in solution, from simple chemical reactions to protein–ligand binding to protein aggregation. Expand
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The SAMPL3 blind prediction challenge: transfer energy overview
TLDR
We present an iterative blind prediction challenge to assess the ability of current computational solvation methods to accurately model the interactions between water and increasingly chlorinated compounds. Expand
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Structural Features of the Glutamate Binding Site in Recombinant NR1/NR2A N-Methyl-d-aspartate Receptors Determined by Site-Directed Mutagenesis and Molecular Modeling
We have used site-directed mutagenesis of amino acids located within the S1 and S2 ligand binding domains of the NR2A N-methyl-d-aspartate (NMDA) receptor subunit to explore the nature of ligandExpand
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Structural Determinants of d-Cycloserine Efficacy at the NR1/NR2C NMDA Receptors
We have studied relative efficacies of NR1 agonists glycine and d-cycloserine (DCS), and found efficacy to be dependent on the NR2 subunit. DCS shows partial agonism at NR1/NR2B but has higherExpand
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Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies
BackgroundPhenylethanolamines selectively bind to NR2B subunit-containing N-methyl-D-aspartate-subtype of ionotropic glutamate receptors and negatively modulate receptor activity. To investigate theExpand
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SiteHopper - a unique tool for binding site comparison
TLDR
SiteHopper is a powerful alternative method to the traditional use of sequence alignment for protein binding sites that is highly flexible and customizable for a variety of end-uses. Expand
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