Matthew Sharp

Learn More
Transgenic technology has been revolutionised by the development of techniques that allow temporo-spatial control of gene deletion or expression in transgenic animals. The ability to switch gene expression 'on' or 'off' in restricted tissues at specific times allows unprecedented flexibility for exploring gene function in both health and disease. As use of(More)
We examine the application of current research in sparse signal recovery to the problem of channel estimation. Specifically, using an Orthogonal Frequency Division Multiplexed (OFDM) transmission scheme with Pilot Symbol Assisted Modulation (PSAM), we consider the problem of identifying a frequency selective channel from a limited number Q out of a possible(More)
—In many communication systems the channel impulse response can be characterized with a parametric form, though the channel estimation is often performed using an equivalent discrete-time linear time-invariant system (usually modeled as a Moving Average (MA) system). When the number of parameters which describe the channel is less than the number of(More)
We have used a metastasis-related human cDNA isolated from a liver metastasis from a colonic adenocarcinoma to screen a human breast carcinoma cDNA library for homologous sequences. Nucleotide sequence analysis of positive clones revealed that the cDNA represents a ribosomal phosphoprotein. P2. The expression of P2 mRNA was significantly higher (Student's t(More)
— We propose an approach that enables increased range and throughput in over-the-horizon (OTH) High Frequency (HF) communications using a novel physical layer node cooperation scheme. By exploiting multiple (and sufficiently spaced apart) low-powered man-portable radios in a collaborative fashion, it will be possible to obtain diversity gains similar to(More)
—Recently, new progress has been made in using basis expansion models for system identification with compressed sensing. To aid the application of these methodologies, we introduce a metric, called localized coherence, for choosing input signals that result in better estimation performance. Its definition is motivated through the analysis of the normalized(More)
The human gene sequences encoding the translation-associated functions of alpha-subunit of elongation factor 1 (EF-1 alpha) and the ubiquitin carboxyl extension protein (HUBCEP80) have been isolated by differential cDNA screening, and found to have significantly higher levels of expression in fibroadenomas (benign) compared with carcinomas (malignant) of(More)
Lesch-Nyhan disease (LND) is a severe neurological disorder caused by loss-of-function mutations in the gene encoding hypoxanthine phosphoribosyltransferase (HPRT), an enzyme required for efficient recycling of purine nucleotides. Although this biochemical defect reconfigures purine metabolism and leads to elevated levels of the breakdown product urea, it(More)
  • 1