Matthew Reilly

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An apparent inverse relationship between smoking and Parkinson's disease prompted an investigation of the effect of chronic nicotine administration on dopaminergic and serotonergic receptors in rat brain. Nicotine, 0.8 mg/kg, was injected once daily, five times per week, for 6 weeks. In nucleus accumbens the Kd for [3H]domperidone was increased 2-4-fold,(More)
The disrupted morphology of lenses in mouse models for cataracts precludes accurate in vitro assessment of lens growth by weight. To overcome this limitation, we developed morphometric methods to assess defects in eye lens growth and shape in mice expressing the alphaA-crystallin R49C (alphaA-R49C) mutation. Our morphometric methods determine quantitative(More)
PURPOSE We qualitatively describe the anatomic features of primary blast ocular injury observed using a postmortem porcine eye model. Porcine eyes were exposed to various levels of blast energy to determine the optimal conditions for future testing. METHODS We studied 53 enucleated porcine eyes: 13 controls and 40 exposed to a range of primary blast(More)
The present study investigated the actions of cocaine and some of its metabolites and analogs upon the synaptosomal (P2) synthesis and release of dopamine appearing from [14C]phenylalanine. Also examined was the influence of reserpine upon these actions of cocaine. The P2 preparations from the rat caudate nucleus were incubated with the drugs for(More)
Much of high performance technical computing has moved from shared memory architectures to message based cluster systems. The development and wide adoption of the MPI parallel programming model has hastened this transition. Parallel scaling, however, is frequently limited by the inefficient communication hardware commonly found in commodity based clusters.(More)
This study expands on a geometric model of ocular accommodation (Reilly and Ravi, Vision Res. 50:330-336; 2010) by relaxing assumptions regarding lens symmetry about the equator. A method for predicting stretching force was derived. Two models were then developed: Model 1 held the equatorial geometry constant at all stages of accommodation, while Model 2(More)
To provide an explanation for earlier paradoxical findings of lithium on survival of mature and immature neurons, this study monitors changes in cytosolic caspases in rat cerebellar granule cells (CGC) grown 2-7 days in vitro (DIV), or in murine E-17 cortical neurons. Data show Li+ protects mature 7-DIV CGC parallel to a decrease in proximal and distal(More)
The objective of this study was to determine whether clinically significant ocular trauma can be induced by a survivable isolated primary blast using a live animal model. Both eyes of 18 Dutch Belted rabbits were exposed to various survivable low-level blast overpressures in a large-scale shock tube simulating a primary blast similar to an improvised(More)
Ocular injury is among the most common terrorist blast morbidities, arising in up to 28% of survivors. Secondary blast injury, in which penetrating and perforating foreign body damage arises from flying debris, is a familiar source of ocular tissue disruption , inflammation and infection. Remarkably, however, the nature and extent of ocular injury from the(More)