Matthew R. Pollock

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Progress of research into the problem of resistance to antibiotics is held back by lack of knowledge of the biochemical mechanisms by which these drugs act. Fortunately, it is possible to study some of the mechanisms of drug resistance, even at a biophysical or biochemical level, without necessarily knowing very much about how the drug works—just as it is(More)
At our present state of knowledge the history of penicillinase began in 1689. I know there was no enzymology in those days, but I'll explain how a little later on. The penicillin and cephalosporin 8t-lactamases are produced by a wide range of Gram-positive and Gram-negative species of bacteria, and differ from each other enormously in the relative rates at(More)