Matthew R. Costa

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Receptors (FcgammaRs) for the constant region of immunoglobulin G (IgG) are an important link between humoral immunity and cellular immunity. To help define the role of FcgammaRs in determining the fate of human immunodeficiency virus type 1 (HIV-1) immune complexes, cDNAs for the four major human Fcgamma receptors (FcgammaRI, FcgammaRIIa, FcgammaRIIb, and(More)
The signatures of the Dissertation Defense Committee signify completion and approval as to style and content of the Dissertation The signature of the Dean of the Graduate School of Biomedical Sciences signifies that the student has met all graduation requirements of the School. Acknowledgments I would first like to thank my mentor, Dr. Shan Lu. He has(More)
HIV-1 is able to elicit broadly potent neutralizing antibodies in a very small subset of individuals only after several years of infection, and therefore, vaccines that elicit these types of antibodies have been difficult to design. The RV144 trial showed that moderate protection is possible and that this protection may correlate with antibody-dependent(More)
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