Matthew R. B. Hardy

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The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1-3),(More)
IFIH1 (interferon induced with helicase C domain 1), also known as MDA5 (melanoma differentiation-associated protein 5), is one of a family of intracellular proteins known to recognise viral RNA and mediate the innate immune response. IFIH1 is causal in type 1 diabetes based on the protective associations of four rare variants, where the derived alleles are(More)
Portable Document Format (PDF) is a page-oriented, graphically rich format based on PostScript semantics and it is also the format interpreted by the Adobe Acrobat viewers. Although each of the pages in a PDF document is an independent graphic object this property does not necessarily extend to the components (headings, diagrams, paragraphs etc.) within a(More)
This paper describes a tool for recombining the logical structure from an XML document with the typeset appearance of the corresponding PDF document. The tool uses the XML representation as a template for the insertion of the logical structure into the existing PDF document thereby creating a Structured/Tagged PDF. The addition of logical structure adds(More)
Documents are often marked up in XML-based tagsets to delineate major structural components such as headings, paragraphs, figure captions and so on, without much regard to their eventual displayed appearance. And yet these same abstract documents, after many transformations and 'typesetting' processes, often emerge in the popular format of Adobe PDF, either(More)
BACKGROUND There is little confidence in the consistency of estimation of DNA concentrations when samples move between laboratories. Evidence on this consistency is largely anecdotal. Therefore there is a need first to measure this consistency among different laboratories and then identify and implement remedies. A pilot experiment to test logistics and(More)
Many billions of documents are stored in the Portable Document Format (PDF). These documents contain a wealth of information and yet PDF is often seen as an inaccessible format and, for that reason, often gets a very bad press. In this tutorial, we get under the hood of PDF and analyze the poor practices that cause PDF files to be inaccessible. We discuss(More)
Accessibility features in the Adobe Portable Document Format (PDF) help facilitate access to electronic information for people with disabilities. This workshop explores how to create accessible PDF documents, from within Adobe Acrobat and other applications; how to use the Adobe Acrobat PDF accessibility checker and repair workflow; best practices for(More)