Matthew Pickford

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A novel drug delivery platform has been developed that utilizes a naturally occurring receptor known as the neonatal Fc receptor (FcRn). The receptor is specific for the Fc fragment of IgG and is expressed in epithelial cells where it functions to transport immunoglobulins across these cell barriers. It has been shown that FcRn is expressed in both the(More)
1. It has been known for some time that the consequences of 'decisions' made at one point in an animal's life may not always be borne immediately. For example, numerous studies have demonstrated the trade-off between current and future breeding success across multiple taxa. 2. It is becoming increasingly clear that such processes may also operate among(More)
Although the visual prognosis for eyes with congenital corneal staphyloma has been considered hopeless, we successfully treated a 1-month-old girl with this condition. We performed two penetrating keratoplasties, operating on the left eye first and then, one week later, on the right eye. During each procedure, we totally resected the staphyloma and excised(More)
As part of a pilot study for glaucoma surgery, the use of 3 infrared solid state lasers with 4 fiber optic delivery systems to ablate human trabecular meshwork was investigated. Laser trabecular ablation (LTA) was attempted with the Erbium:YAG (2.94 microns), Erbium:YSGG (2.79 microns), and Holmium:YSGG (2.1 microns) lasers. Laser energy was delivered as a(More)
Visible light-induced photoreceptor cell damage resulting from exposure to multiple intermittent light-dark periods was compared with damage resulting from continuous light in albino rats maintained in a weak cyclic-light environment or in darkness before light treatment. The time course of retinal damage was determined by correlative measurements of(More)
Purpose. To assess the pulmonary deposition and pharmacokinetics of an engineered PulmoSphere® powder relative to standard micronized drug when delivered from passive dry powder inhalers (DPIs). Methods. Budesonide PulmoSphere (PSbud) powder was manufactured using an emulsion-based spray-drying process. Eight healthy subjects completed 3 treatments in(More)
In dark-reared albino rats, exposure to 2 or 3 hr of intense light interrupted by 2 hr dark periods resulted in extensive degeneration of photoreceptor cells and degeneration of the retinal pigment epithelium (RPE). Ascorbate (ie, vitamin C) administration prior to light exposure protected photoreceptors and the RPE from light damage. In the present study,(More)
The effect of intraocular liquid silicone on the electroretinogram (ERG) and on retinal morphology was studied in rabbits. After vitrectomy, liquid silicone (1000 centistokes) or balanced salt solution (BSS) was injected into the eyes. The intraocular silicone was well tolerated clinically in all eyes that were followed over a period of 3 days to 6 months.(More)