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Pituitary adenomas (PAs) are neoplasms that may cause a variety of neurological and endocrine effects. Although known causal contributors include heredity, hormonal influence and somatic mutations, the pathophysiologic mechanisms driving tumorigenesis and invasion of sporadic PAs remain unknown. We hypothesized that alterations in DNA methylation are(More)
BACKGROUND Pituitary adenomas (PAs) are commonly occurring neoplasms with diverse endocrine and neurological effects. Although somatic gene mutations are uncommon in sporadic PAs, recent studies lend support to epigenetic modification as a potential cause of tumorigenesis and tumor progression. METHODS A systematic literature review of the PubMed and(More)
INTRODUCTION A single-center study to define the sensitivity and specificity of intraoperative neurophysiological monitoring in detecting new neurological deficits. METHODS A cohort of 4989 consecutive (2962 male and 2027 female) patients operated on over 3 years was evaluated. Subgroup analysis was performed for patients undergoing posterior cervical(More)
Background Oculorrhea, or cerebrospinal fluid leakage developing from a cranio-orbital fistula, is a rare development following traumatic injury. Case Report A 22-year-old man involved in a motor vehicle accident developed a blowout fracture of the left orbital roof penetrating the frontal lobe, inducing oculorrhea. He underwent a supraorbital craniotomy(More)
OBJECT A more comprehensive understanding of the epigenetic abnormalities associated with meningioma tumorigenesis, growth, and invasion may provide useful targets for molecular classification and development of targeted therapies for meningiomas. METHODS The authors performed a review of the current literature to identify the epigenetic modifications(More)
In heart transplant recipients but not in normal humans, total peripheral vascular resistance increases during static exercise. To determine whether this augmented vasoconstriction limits the vasodilation normally seen in the nonexercising forearm, we measured arterial pressure, heart rate, and forearm blood flow during 30% maximal static handgrip in 9(More)
We evaluated 74 peripheral vascular disease (PVD) patients (54 men, age 61 +/- 7 years and 17 women, age 63 +/- 7 years) for potential coronary heart disease (CAD) using an arm exercise test (AET) protocol. All patients performed upright two-arm cranking using discontinuous stages of 2 minutes of exercise separated by 2 minutes of rest. Exercise intensity(More)
BACKGROUND Hospital-acquired conditions (HACs) are defined by the Centers for Medicaid and Medicare Services (CMS) as preventable adverse events that do not qualify for reimbursement of resulting hospital costs. HACs have been employed as a metric for quality of patient care. Patients undergoing cervical spine fusions are at risk for occurrence of HACs(More)
OBJECTIVES The objectives of the present study were (1) to evaluate the pressor response to an isometric handgrip exercise in normotensive black and white males; (2) to measure plasma catecholamine levels pre- and post-exercise, as an index of sympathetic nervous system activity; and (3) to quantify the pressor response to bolus intravenous injections of(More)
This paper presents a novel experiment on group conflict. Subjects are divided into groups according to preferences on paintings, and subjects are divided into groups according to self-declared political affiliations and leanings. Using a unique within subject design, we find twenty percent of subjects destroy social welfare – at personal cost – when facing(More)