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Etazolate is a phosphodiesterase 4 (PDE4) inhibitor and GABAA receptor modulator that also stimulates alpha-secretase activity and neurotrophic soluble amyloid precursor protein (sAPPalpha) production, currently developed as a possible Alzheimer's disease therapeutic. In this study two doses of etazolate were tested for cognitive effects in normally aged(More)
Chemotherapeutic agents simultaneously induce transcription factors p53 and NF␬B. p53 induction can activate an apo-ptotic program, and resistance to chemotherapy correlates with the loss of a functional p53 pathway. By contrast, NF␬B prevents apoptosis in response to chemotherapeutic agents. We have analyzed the p53 response in IKK1/2 Ϫ/Ϫ MEFs, which lack(More)
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