Matthew P Sherman

Learn More
Utilization of fatty acids such as oleic acid as sole carbon source by the yeast Saccharomyces cerevisiae requires coordinated function of peroxisomes, where the fatty acids are degraded, and the mitochondria, where oxidation is completed. We identified two mitochondrial oxodicarboxylate transporters, Odc1p and Odc2p, as important in efficient utilization(More)
Nitroxyl, or nitrosyl hydride, (HNO) is a pharmacologically relevant molecule whose physiological responses have been thought to result from modification of intracellular thiols. The reaction of HNO with thiols has been shown to lead to disulfides and sulfinamides. The free energies of reaction (DeltaG) and activation (DeltaG(++)) were determined for the(More)
Computational methods are used to investigate the mechanism by which fluorination of acetylnitrene reduces the stabilization of the singlet configuration. ΔEST is made more positive (favoring the triplet state) by 1.9, 1.3, and 0.7 kcal/mol by the addition of the first, second, and third fluorine, respectively, at the(More)
It is possible to objectively determine whether a detona tion can propagate in a given geometry (volume shape and size, obstacle configuration, degree of confinement) for a given mixture composition (concentrations of hydrogen, air and steam); this is done by conservatively equating the detonation propaga tion criteria with the criteria for transition from(More)
  • 1