Matthew Ninan

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Signaling through the phosphatidylinositol 3-kinase (PI3-kinase) pathway has been associated with lung tumorigenesis. We examined the association between gene copy number of the PI3-kinase catalytic subunit alpha (PIK3CA) and phosphorylated Akt expression in invasive and preinvasive lung cancers. We sought to determine at what stage of tumor development(More)
Approximately 33% of patients with renal cell carcinoma will present with metastases. Patients have a reported 35% 5-year survival rate in instances in which nephrectomy and surgical resection of a solitary metastasis have been performed. Laparoscopic partial nephrectomy has become an increasingly viable option in the treatment of some renal cancers. We(More)
7513 Background: Metastasis to lymph nodes (LN) connotes poor prognosis in NSCLC. Sufficient LN must be examined to accurately determine LN negativity. Patients with no LN examined (pNx) may be incompletely staged and erroneously assigned to a low risk group. To evaluate this possibility, we compared the survival of patients with node negative disease and(More)
6646 Background: HDC and ASCT often lead to infectious and non-infectious PC. Non-infectious PC includes interstitial pneumonitis, bronchiolitis obliterans (BO), BO with organizing pneumonia (BOOP), and diffuse alveolar hemorrhage. Patients (pts.) often undergo bronchoscopy with bronchoalveolar lavage (BAL) and transbronchial biopsy (TBB) to establish a(More)
7512 Background: Curative treatment of early stage NSCLC requires good quality oncologic resection (GQR). For GQR, the National Comprehensive Cancer Network (NCCN) requires a minimum of segmentectomy, negative margins, lymph node (LN) sampling from stations 10-14 (level-1) and >2 mediastinal (level-2) stations. We reviewed details of consecutive resections(More)
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