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Metabotropic glutamate receptor subtype 5 (mGluR5) dysfunction has been implicated in several disorders. [11C]ABP688, a positron emission tomography (PET) ligand targeting mGluR5, could be a valuable(More)
Serotonin1A (5-HT1A) receptors exist in high- and low-affinity states, and agonist ligands bind preferentially to the high-affinity state of the receptor and provide a measure of functional 5-HT1A(More)
OBJECTIVE To explore the concept of the negative syndrome as a dimensional entity that exists in multiple primary diagnoses, and to compare the negative syndrome in nonschizophrenic disorders and(More)